Specific recognition of O⁶-methylguanine in DNA by active site mutants of human O⁶-methylguanine-DNA methyltransferase

Keyphrases

• O6-methylguanine-DNA Methyltransferase 100%
• Methylguanine Methyltransferase 100%
• Specific Recognition 100%
• Active Site mutant 100%
• O6-benzylguanine 100%
• Mutant Protein 42%
• Active Sites 28%
• Carboxyl Terminus 28%
• Substrate Binding 28%
• Stable Complexes 28%
• NMR Spectroscopy 14%
• X-ray Crystallography 14%
• Structural Change 14%
• Amino Acid Residues 14%
• Tertiary Structure 14%
• DNA Adducts 14%
• Carcinogen 14%
• Oligonucleotides 14%
• DNA Repair Enzymes 14%
• DNase 14%
• Digestion 14%
• Footprinting 14%
• Alkylation 14%
• Cysteine 14%
• Bound Form 14%
• Amino-terminus 14%
• Reaction Mechanism 14%
• Alkyl Group 14%
• NMR Studies 14%
• Deletion Analysis 14%
• Transient Intermediates 14%
• Discriminatory Effects 14%
• Systematic Deletions 14%
• Stoichiometric Reaction 14%
• Complementary Strand 14%
• NMR Spectroscopic Analysis 14%
• Protease Sensitivity 14%
• Bacterial Overexpression 14%
• Distal Residues 14%

Biochemistry, Genetics and Molecular Biology

• Active Site 100%
• DNA Methyltransferase 100%
• 6-O-Methylguanine 100%
• Mutant Protein 33%
• Wild Type 22%
• C-Terminus 22%
• Nucleotide 22%
• Oligonucleotide 11%
• Tertiary Structure 11%
• Amino Acids 11%
• N-Terminus 11%
• DNA Repair Protein 11%
• Deoxyribonuclease I 11%
• Methyltransferase 11%
• DNA Adduct 11%
• X-Ray Crystallography 11%
• Protease 11%
• Arginine 11%
• Cysteine 11%
• Nuclear Magnetic Resonance Spectroscopy 11%