Specificity of noninvasive blood glucose monitoring with optical coherence tomography

Kirill V. Larin, Taras V. Ashitkov, Massoud Motamedi, Rinat O. Esenaliev

Research output: Contribution to journalConference article

1 Scopus citations

Abstract

Management of diabetic disease requires frequent monitoring of blood glucose concentration. Development of a noninvasive technique capable of reliable and sensitive monitoring of blood glucose concentration would considerably improve quality of life of diabetic patients and reduce mortality associated with this disease. Recently, we proposed to use Optical Coherence Tomography (OCT) technique for noninvasive glucose monitoring. In this paper, we tested in animals several aspects of specificity of noninvasive blood glucose monitoring with the OCT technique. Influence of temperature and tissue heterogeneity on the OCT signal profile is experimentally studied in this paper. We also theoretically investigated the changes in tissue scattering induced by variation of concentration of glucose and other osmolytes. Obtained results suggest that although several physical and chemical agents could potentially interfere with blood glucose concentration measurements using the OCT technique, their effect is smaller compared to that of glucose under normal physiological conditions.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4965
DOIs
StatePublished - Dec 5 2003
EventPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Diagnostics and Sensing in Biomedicine III - San Jose, CA, United States
Duration: Jan 28 2003Jan 29 2003

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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