Abstract
Noninvasive monitoring of blood glucose concentration in diabetic patients would significantly reduce complications and mortality associated with this disease. In this paper, we experimentally and theoretically studied specificity of noninvasive blood glucose monitoring with the optical coherence tomography (OCT) technique. OCT images and signals were obtained from skin of Yucatan micropigs and New Zealand rabbits. Obtained results demonstrate that: (1) several body osmolytes may change the refractive index mismatch between the interstitial fluid (ISF) and scattering centres in tissue, however the effect of the glucose is approximately one to two orders of magnitude higher; (2) an increase of the ISF glucose concentration in the physiological range (3-30 mM) may decrease the scattering coefficient by 0.22% mM-1 due to cell volume change; (3) stability of the OCT signal slope is dependent on tissue heterogeneity and motion artefacts; and (4) moderate skin temperature fluctuations (±1 °C) do not decrease accuracy and specificity of the OCT-based glucose sensor, however substantial skin heating or cooling (several °C) significantly change the OCT signal slope. These results suggest that the OCT technique may provide blood glucose concentration monitoring with sufficient specificity under normal physiological conditions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1371-1390 |
| Number of pages | 20 |
| Journal | Physics in Medicine and Biology |
| Volume | 48 |
| Issue number | 10 |
| DOIs | |
| State | Published - May 21 2003 |
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ASJC Scopus subject areas
- Biomedical Engineering
- Physics and Astronomy (miscellaneous)
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Specificity of noninvasive blood glucose sensing using optical coherence tomography technique : A pilot study. / Larin, Kirill V.; Motamedi, Massoud; Ashitkov, Taras V.; Esenaliev, Rinat.
In: Physics in Medicine and Biology, Vol. 48, No. 10, 21.05.2003, p. 1371-1390.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Specificity of noninvasive blood glucose sensing using optical coherence tomography technique
T2 - A pilot study
AU - Larin, Kirill V.
AU - Motamedi, Massoud
AU - Ashitkov, Taras V.
AU - Esenaliev, Rinat
PY - 2003/5/21
Y1 - 2003/5/21
N2 - Noninvasive monitoring of blood glucose concentration in diabetic patients would significantly reduce complications and mortality associated with this disease. In this paper, we experimentally and theoretically studied specificity of noninvasive blood glucose monitoring with the optical coherence tomography (OCT) technique. OCT images and signals were obtained from skin of Yucatan micropigs and New Zealand rabbits. Obtained results demonstrate that: (1) several body osmolytes may change the refractive index mismatch between the interstitial fluid (ISF) and scattering centres in tissue, however the effect of the glucose is approximately one to two orders of magnitude higher; (2) an increase of the ISF glucose concentration in the physiological range (3-30 mM) may decrease the scattering coefficient by 0.22% mM-1 due to cell volume change; (3) stability of the OCT signal slope is dependent on tissue heterogeneity and motion artefacts; and (4) moderate skin temperature fluctuations (±1 °C) do not decrease accuracy and specificity of the OCT-based glucose sensor, however substantial skin heating or cooling (several °C) significantly change the OCT signal slope. These results suggest that the OCT technique may provide blood glucose concentration monitoring with sufficient specificity under normal physiological conditions.
AB - Noninvasive monitoring of blood glucose concentration in diabetic patients would significantly reduce complications and mortality associated with this disease. In this paper, we experimentally and theoretically studied specificity of noninvasive blood glucose monitoring with the optical coherence tomography (OCT) technique. OCT images and signals were obtained from skin of Yucatan micropigs and New Zealand rabbits. Obtained results demonstrate that: (1) several body osmolytes may change the refractive index mismatch between the interstitial fluid (ISF) and scattering centres in tissue, however the effect of the glucose is approximately one to two orders of magnitude higher; (2) an increase of the ISF glucose concentration in the physiological range (3-30 mM) may decrease the scattering coefficient by 0.22% mM-1 due to cell volume change; (3) stability of the OCT signal slope is dependent on tissue heterogeneity and motion artefacts; and (4) moderate skin temperature fluctuations (±1 °C) do not decrease accuracy and specificity of the OCT-based glucose sensor, however substantial skin heating or cooling (several °C) significantly change the OCT signal slope. These results suggest that the OCT technique may provide blood glucose concentration monitoring with sufficient specificity under normal physiological conditions.
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U2 - 10.1088/0031-9155/48/10/310
DO - 10.1088/0031-9155/48/10/310
M3 - Article
VL - 48
SP - 1371
EP - 1390
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
SN - 0031-9155
IS - 10
ER -