Specificity of noninvasive blood glucose sensing using optical coherence tomography technique: A pilot study

Kirill V. Larin, Massoud Motamedi, Taras V. Ashitkov, Rinat Esenaliev

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Noninvasive monitoring of blood glucose concentration in diabetic patients would significantly reduce complications and mortality associated with this disease. In this paper, we experimentally and theoretically studied specificity of noninvasive blood glucose monitoring with the optical coherence tomography (OCT) technique. OCT images and signals were obtained from skin of Yucatan micropigs and New Zealand rabbits. Obtained results demonstrate that: (1) several body osmolytes may change the refractive index mismatch between the interstitial fluid (ISF) and scattering centres in tissue, however the effect of the glucose is approximately one to two orders of magnitude higher; (2) an increase of the ISF glucose concentration in the physiological range (3-30 mM) may decrease the scattering coefficient by 0.22% mM-1 due to cell volume change; (3) stability of the OCT signal slope is dependent on tissue heterogeneity and motion artefacts; and (4) moderate skin temperature fluctuations (±1 °C) do not decrease accuracy and specificity of the OCT-based glucose sensor, however substantial skin heating or cooling (several °C) significantly change the OCT signal slope. These results suggest that the OCT technique may provide blood glucose concentration monitoring with sufficient specificity under normal physiological conditions.

Original languageEnglish (US)
Pages (from-to)1371-1390
Number of pages20
JournalPhysics in Medicine and Biology
Volume48
Issue number10
DOIs
StatePublished - May 21 2003

Fingerprint

Optical tomography
Optical Coherence Tomography
glucose
blood
Glucose
Blood Glucose
Blood
tomography
Skin
Extracellular Fluid
Monitoring
interstitials
Scattering
Tissue
slopes
Glucose sensors
Refractometry
Fluids
Skin Temperature
mortality

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Specificity of noninvasive blood glucose sensing using optical coherence tomography technique : A pilot study. / Larin, Kirill V.; Motamedi, Massoud; Ashitkov, Taras V.; Esenaliev, Rinat.

In: Physics in Medicine and Biology, Vol. 48, No. 10, 21.05.2003, p. 1371-1390.

Research output: Contribution to journalArticle

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