Speckle noise suppression for quantitative analysis of tissue optical properties with OCT

I. Y. Petrova, A. I. Kholodnykh, K. V. Larin, M. Motamedi, R. O. Esenaliev

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations


Measurement of tissue optical properties can be used for noninvasive monitoring of analytes and tissue characterization. Noninvasive measurement of tissue optical properties (attenuation, scattering coefficient, optical thickness, etc.) can be performed with optical coherence tomography (OCT) technique. However, speckle noise substantially deteriorates the accuracy of the measurements with this technique. In this paper, we studied suppression of speckle noise for accurate measurement of backscattering signal with the OCT technique. The backscattering signal variance resulted from speckle noise was experimentally determined for a scattering standard and human skin. The dependence of speckle and electronic noise on the range of spatial and temporal averaging of OCT signals was studied. Our results demonstrated that the accuracy of measurement of backscattering signals with OCT technique from skin can be 0.65% and may reach 0.1-0.2% if optimum averaging parameters are used.

Original languageEnglish (US)
Pages (from-to)2255-2256
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
StatePublished - 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002


  • Glucose sensing
  • Laser interferometry
  • Optical coherence tomography
  • Speckles

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics


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