Spectroscopic characterization of chemokines: relevance for quality control and standardization.

Krishna Rajarathnam, M. P. Crump, I. Clark-Lewis, B. D. Sykes

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Chemokines are mediators of inflammation and trafficking of cells of the immune system including a pivotal role in the recruitment and activation of leukocytes. Due to their involvement in a variety of disease processes, chemokines are potential therapeutic targets. The use of chemokines as pharmaceuticals will require that the folded state and the association properties of the protein are well characterized. In this report, we describe the utility of nuclear magnetic resonance spectroscopy as a tool to study these aspects of chemokine structural properties.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalDevelopments in Biological Standardization
Volume97
StatePublished - 1999
Externally publishedYes

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Chemokines
Quality Control
Inflammation Mediators
Immune System
Leukocytes
Magnetic Resonance Spectroscopy
Pharmaceutical Preparations
Proteins
Therapeutics

ASJC Scopus subject areas

  • Biotechnology

Cite this

Spectroscopic characterization of chemokines : relevance for quality control and standardization. / Rajarathnam, Krishna; Crump, M. P.; Clark-Lewis, I.; Sykes, B. D.

In: Developments in Biological Standardization, Vol. 97, 1999, p. 49-57.

Research output: Contribution to journalArticle

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