Speed-stability paradox in DNA-scanning by zinc-finger proteins

Junji Iwahara; Yaakov Levy

doi:10.4161/trns.23584

Speed-stability paradox in DNA-scanning by zinc-finger proteins

Junji Iwahara, Yaakov Levy

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Extensive contact with DNA via multiple zinc fingers allows highly specific DNA-binding of zinc-finger-class transcription factors, but can also slow the target search process. Here we introduce recent insights into how zinc-finger proteins can rapidly scan DNA. Potential application of the new knowledge to the zinc-finger-based technology is also discussed.

Original language	English (US)
Journal	Transcription
Volume	4
Issue number	2
DOIs	https://doi.org/10.4161/trns.23584
State	Published - 2013

Keywords

DNA-scanning
Dynamics
Gene control
Kinetics
Target search
Zinc-finger nucleases
Zinc-finger transcription factors

ASJC Scopus subject areas

Genetics
Biochemistry
Biotechnology

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10.4161/trns.23584

Cite this

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title = "Speed-stability paradox in DNA-scanning by zinc-finger proteins",

abstract = "Extensive contact with DNA via multiple zinc fingers allows highly specific DNA-binding of zinc-finger-class transcription factors, but can also slow the target search process. Here we introduce recent insights into how zinc-finger proteins can rapidly scan DNA. Potential application of the new knowledge to the zinc-finger-based technology is also discussed.",

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AB - Extensive contact with DNA via multiple zinc fingers allows highly specific DNA-binding of zinc-finger-class transcription factors, but can also slow the target search process. Here we introduce recent insights into how zinc-finger proteins can rapidly scan DNA. Potential application of the new knowledge to the zinc-finger-based technology is also discussed.

KW - DNA-scanning

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KW - Gene control

KW - Kinetics

KW - Target search

KW - Zinc-finger nucleases

KW - Zinc-finger transcription factors

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Speed-stability paradox in DNA-scanning by zinc-finger proteins

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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