Speed-stability paradox in DNA-scanning by zinc-finger proteins

Junji Iwahara, Yaakov Levy

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Extensive contact with DNA via multiple zinc fingers allows highly specific DNA-binding of zinc-finger-class transcription factors, but can also slow the target search process. Here we introduce recent insights into how zinc-finger proteins can rapidly scan DNA. Potential application of the new knowledge to the zinc-finger-based technology is also discussed.

Original languageEnglish (US)
Pages (from-to)58-61
Number of pages4
JournalTranscription
Volume4
Issue number2
DOIs
StatePublished - Jan 1 2013

Keywords

  • DNA-scanning
  • dynamics
  • gene control
  • kinetics
  • target search
  • zinc-finger nucleases
  • zinc-finger transcription factors

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics

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