Speed-stability paradox in DNA-scanning by zinc-finger proteins

Junji Iwahara, Yaakov Levy

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Extensive contact with DNA via multiple zinc fingers allows highly specific DNA-binding of zinc-finger-class transcription factors, but can also slow the target search process. Here we introduce recent insights into how zinc-finger proteins can rapidly scan DNA. Potential application of the new knowledge to the zinc-finger-based technology is also discussed.

Original languageEnglish (US)
JournalTranscription
Volume4
Issue number2
DOIs
StatePublished - 2013

Fingerprint

Zinc Fingers
Zinc
Scanning
DNA
Proteins
Transcription Factors
Technology

Keywords

  • DNA-scanning
  • Dynamics
  • Gene control
  • Kinetics
  • Target search
  • Zinc-finger nucleases
  • Zinc-finger transcription factors

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Genetics

Cite this

Speed-stability paradox in DNA-scanning by zinc-finger proteins. / Iwahara, Junji; Levy, Yaakov.

In: Transcription, Vol. 4, No. 2, 2013.

Research output: Contribution to journalArticle

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