Spin-Valve based magnetoresistive nanoparticle detector for applications in biosensing

Wenlan Qiu, Long Chang, Yu Chi Liang, Julia Litvinov, Jing Guo, Yi Ting Chen, Binh Vu, Katerina Kourentzi, Shoujun Xu, T. Randall Lee, Youli Zu, Richard C. Willson, Dmitri Litvinov

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A magnetoresistive sensor platform for the detection of individual magnetic reporter particles is presented. The sensing scheme is based on the detection of the shift in the sensor's magnetoresistance-switching field in the presence of magnetic particle(s). A bottom-pinned spin-valve multilayer (Co/Ru/Co)/Cu/(Co/Ru/Co) device structure (with Ta/Ru seed and Ta capping layers) used for the sensor was deposited using ultra-high vacuum magnetron sputtering and patterned using conventional microfabrication techniques. Inexpensive electronics to measure device magnetoresistance (using DC currents) was used for testing. The detection of individual 500 nm Fe3O4 nanoparticles as well as the detection of up to ten (10) nanoparticles was demonstrated and verified using scanning electron microscopy (SEM). The developed sensors are readily integratable into a biosensing platform for the detection of biomolecules at ultra-low concentration using magnetic nanoparticles as reporters.

Original languageEnglish (US)
Pages (from-to)174-180
Number of pages7
JournalSensors and Actuators, A: Physical
Volume265
DOIs
StatePublished - Oct 1 2017

Fingerprint

Nanoparticles
Detectors
nanoparticles
detectors
Sensors
Magnetoresistance
sensors
Microfabrication
Ultrahigh vacuum
Biomolecules
platforms
Magnetron sputtering
Seed
Multilayers
Electronic equipment
Scanning electron microscopy
ultrahigh vacuum
seeds
low concentrations
magnetron sputtering

Keywords

  • Bioinstrumentation
  • Biosensor
  • Magnetic particle detection
  • Magnetoresistive sensors

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering

Cite this

Qiu, W., Chang, L., Liang, Y. C., Litvinov, J., Guo, J., Chen, Y. T., ... Litvinov, D. (2017). Spin-Valve based magnetoresistive nanoparticle detector for applications in biosensing. Sensors and Actuators, A: Physical, 265, 174-180. https://doi.org/10.1016/j.sna.2017.08.018

Spin-Valve based magnetoresistive nanoparticle detector for applications in biosensing. / Qiu, Wenlan; Chang, Long; Liang, Yu Chi; Litvinov, Julia; Guo, Jing; Chen, Yi Ting; Vu, Binh; Kourentzi, Katerina; Xu, Shoujun; Lee, T. Randall; Zu, Youli; Willson, Richard C.; Litvinov, Dmitri.

In: Sensors and Actuators, A: Physical, Vol. 265, 01.10.2017, p. 174-180.

Research output: Contribution to journalArticle

Qiu, W, Chang, L, Liang, YC, Litvinov, J, Guo, J, Chen, YT, Vu, B, Kourentzi, K, Xu, S, Lee, TR, Zu, Y, Willson, RC & Litvinov, D 2017, 'Spin-Valve based magnetoresistive nanoparticle detector for applications in biosensing', Sensors and Actuators, A: Physical, vol. 265, pp. 174-180. https://doi.org/10.1016/j.sna.2017.08.018
Qiu, Wenlan ; Chang, Long ; Liang, Yu Chi ; Litvinov, Julia ; Guo, Jing ; Chen, Yi Ting ; Vu, Binh ; Kourentzi, Katerina ; Xu, Shoujun ; Lee, T. Randall ; Zu, Youli ; Willson, Richard C. ; Litvinov, Dmitri. / Spin-Valve based magnetoresistive nanoparticle detector for applications in biosensing. In: Sensors and Actuators, A: Physical. 2017 ; Vol. 265. pp. 174-180.
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