Spinal projections of pelvic visceral afferents of the rat

A calcitonin gene-related peptide (CGRP) immunohistochemical study

K. Chung, W. T. Lee, M. J. Park

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Little information is available concerning the pelvic visceral afferent system, in view of its terminal location in the spinal cord and its associated transmitter substances in the rat. By utilizing an immunostaining method to examine the transneuronal neurotransmitter depletion resulting from peripheral sensory nerve injury, the spinal projections of primary afferent fibers containing calcitonin gene-related peptide (CGRP) and originating from pelvic viscera were studied in the lumbosacral spinal cord of the rat. After unilateral or bilateral pelvic nerve section, CGRP immunoreactivity in the lumbosacral spinal cord was decreased greatly in the sacral parasympathetic nucleus (SPN), the dorsolateral fasciculus, the medial border of the dorsal horn, the dorsal gray commissure (DGC), and the intermediate gray connecting the SPN and DGC. Fine structural analysis showed that the CGRP- immunoreactive terminals made synaptic contact with dendrites and, rarely, with somata. Although there was some incidence of a synaptic contact between a CGRP-IR terminal and a vesicle-containing profile, definite evidence of axo-axonal synapse has not been confirmed. These data indicate that CGRP- containing pelvic visceral primary afferent fibers project to autonomic areas of the lumbosacral spinal cord by way of the pelvic nerve and make synaptic contact with dendrites and somata.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalJournal of Comparative Neurology
Volume337
Issue number1
DOIs
StatePublished - 1993

Fingerprint

Visceral Afferents
Calcitonin Gene-Related Peptide
Spinal Cord
Carisoprodol
Dendrites
Peripheral Nerve Injuries
Viscera
Presynaptic Terminals
Synapses
Neurotransmitter Agents
Incidence

Keywords

  • CGRP-immunoreactivity
  • sacral parasympathetic
  • spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Spinal projections of pelvic visceral afferents of the rat : A calcitonin gene-related peptide (CGRP) immunohistochemical study. / Chung, K.; Lee, W. T.; Park, M. J.

In: Journal of Comparative Neurology, Vol. 337, No. 1, 1993, p. 63-69.

Research output: Contribution to journalArticle

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