Spindle cell hemangioendothelioma: Report of three cases and review of the literature

M. Eltorky, T. M. Chesney, J. Sebes, J. C. Hall

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

BACKGROUND. Spindle cell hemangioendothelioma lesions are uncommon, affect a wide age range in both sexes, and show a predilection for skin and subcutaneous tissue of the extremities. OBJECTIVE. To present three cases of spindle cell hemangioendothelioma and review the literature. METHODS. Three cases of spindle cell hemangioendothelioma are presented. RESULTS. Two of our cases first presented very early in life and progressed by local recurrences over many years. None of our cases showed evidence of metastases, but the lesions exhibited local aggressive and invasive behavior. Histologically, the lesions consist of alternating areas of dilated, thin walled cavernous vascular spaces and solid areas composed predominantly of spindle cells and clusters of epithelioid endothelial cells with intracytoplasmic vacuoles. That spindle cell hemangioendothelioma is a non-neoplastic lesion and not a neoplasm of borderline malignancy is suggested by the following observations from our cases: the repeated presence of organized intravascular thrombi in all cases, the early clinical presentation in two cases, and the presence of some degree of vascular malformation at the periphery of lesions. CONCLUSION. Both clinicians and pathologists should be aware of the existence of this lesion in order to diagnose and treat an affected patient correctly.

Original languageEnglish (US)
Pages (from-to)196-202
Number of pages7
JournalJournal of Dermatologic Surgery and Oncology
Volume20
Issue number3
StatePublished - 1994
Externally publishedYes

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Hemangioendothelioma
Epithelioid Cells
Vascular Malformations
Subcutaneous Tissue
Vacuoles
Blood Vessels
Neoplasms
Thrombosis
Extremities
Endothelial Cells
Neoplasm Metastasis
Recurrence
Skin

ASJC Scopus subject areas

  • Dermatology
  • Oncology

Cite this

Spindle cell hemangioendothelioma : Report of three cases and review of the literature. / Eltorky, M.; Chesney, T. M.; Sebes, J.; Hall, J. C.

In: Journal of Dermatologic Surgery and Oncology, Vol. 20, No. 3, 1994, p. 196-202.

Research output: Contribution to journalArticle

Eltorky, M. ; Chesney, T. M. ; Sebes, J. ; Hall, J. C. / Spindle cell hemangioendothelioma : Report of three cases and review of the literature. In: Journal of Dermatologic Surgery and Oncology. 1994 ; Vol. 20, No. 3. pp. 196-202.
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