Splenectomy attenuates the inappropriate diuresis associated with tumor necrosis factor administration

J. J B Van Lanschot, K. Mealy, D. O. Jacobs, D. A. Evans, D. W. Wilmore

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Tumor necrosis factor (TNF) is an important mediator of the systemic response to gram-negative sepsis and endotoxemia. We studied the renal effects of a sublethal TNF infusion in dogs (0.54=105 international units per kilogram of body weight during a six hour period). The TNF-infused dogs (n=4) had marked polyuria and natriuresis in comparison with those in the control group (n=12) (urine output, 35.3±4.1 versus 3.7±0.5 millimeters per kilogram per six hours p<0.01; sodium excretion, 2.82±0.27 versus 0.75±0.19, p<0.01). To evaluate the role of the spleen in this response, seven dogs that had splenectomy were infused with TNF. Splenectomy abolished both the polyuria and the natriuresis; this could not be explained by the differences in fluid balance or in hemodynamic or metabolic alterations. Treatment with ibuprofen given intravenously (12.5 milligrams per kilogram 40 minutes before and three hours after the beginning of TNF infusion) in eight dogs that did not undergo splenectomy also abolished these renal effects. Prostaglandin 2 (PGE2) concentrations in selected blood samples from the splenic vein did not increase with TNF infusion, excluding circulating PGE2 as a possible mediator of the renal effects. The results of these studies indicate that, during septic challenge or severe inflammation, the spleen participates in signaling the kidney to increase water and sodium excretion. These renal events are mediated through the cyclo-oxygenase pathway.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalSurgery Gynecology and Obstetrics
Volume172
Issue number4
StatePublished - 1991
Externally publishedYes

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Diuresis
Splenectomy
Tumor Necrosis Factor-alpha
Kidney
Dogs
Polyuria
Natriuresis
Dinoprostone
Spleen
Sodium
Splenic Vein
Endotoxemia
Water-Electrolyte Balance
Ibuprofen
Prostaglandin-Endoperoxide Synthases
Prostaglandins
Sepsis
Hemodynamics
Body Weight
Urine

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Surgery

Cite this

Van Lanschot, J. J. B., Mealy, K., Jacobs, D. O., Evans, D. A., & Wilmore, D. W. (1991). Splenectomy attenuates the inappropriate diuresis associated with tumor necrosis factor administration. Surgery Gynecology and Obstetrics, 172(4), 293-297.

Splenectomy attenuates the inappropriate diuresis associated with tumor necrosis factor administration. / Van Lanschot, J. J B; Mealy, K.; Jacobs, D. O.; Evans, D. A.; Wilmore, D. W.

In: Surgery Gynecology and Obstetrics, Vol. 172, No. 4, 1991, p. 293-297.

Research output: Contribution to journalArticle

Van Lanschot, JJB, Mealy, K, Jacobs, DO, Evans, DA & Wilmore, DW 1991, 'Splenectomy attenuates the inappropriate diuresis associated with tumor necrosis factor administration', Surgery Gynecology and Obstetrics, vol. 172, no. 4, pp. 293-297.
Van Lanschot, J. J B ; Mealy, K. ; Jacobs, D. O. ; Evans, D. A. ; Wilmore, D. W. / Splenectomy attenuates the inappropriate diuresis associated with tumor necrosis factor administration. In: Surgery Gynecology and Obstetrics. 1991 ; Vol. 172, No. 4. pp. 293-297.
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