Spontaneous cerebrospinal fluid leak repair

A five-year prospective evaluation

Mohamad Chaaban, Elisa Illing, Kristen O. Riley, Bradford A. Woodworth

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Objectives/Hypothesis Mounting evidence indicates the majority of spontaneous cerebrospinal fluid (CSF) leaks are associated with intracranial hypertension. The objectives of the current study were to assess outcomes regarding spontaneous CSF leaks focusing on premorbid factors, surgical technique, and management of intracranial pressure. Study Design Prospective cohort. Methods Prospective evaluation of patients with spontaneous CSF leaks was performed. Data regarding demographics, nature of presentation, body mass index (BMI), location and size of defect, intracranial pressure, clinical follow-up, and complications were collected. Results Over 5 years, 46 patients (average age, 51 years) with 56 spontaneous CSF leaks were treated by a single otolaryngologist. Twenty-one subjects presented with recurrence of their CSF leak following previous endoscopic and/or open approaches by other physicians. Obesity was present in 78% of individuals (average BMI, 35.6). Fifty-two CSF leaks (93%) were successfully repaired at first attempt. With secondary repair, all CSF leaks were closed at last clinical follow-up (average, 93 weeks). Three patients developed late failures (>2 months), with one recurrence at a distinct location from the primary site at 8 months postprocedure (associated with ventriculoperitoneal shunt failure). Opening pressures via lumbar puncture averaged 24.3 ± 8.3 cm H20, which increased significantly to 32.3 ± 9.0 cm H20 (P

Original languageEnglish (US)
Pages (from-to)70-75
Number of pages6
JournalLaryngoscope
Volume124
Issue number1
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Intracranial Pressure
Body Mass Index
Ventriculoperitoneal Shunt
Recurrence
Spinal Puncture
Intracranial Hypertension
Cerebrospinal Fluid Leak
Obesity
Demography
Prospective Studies
Physicians
Pressure
Otolaryngologists

Keywords

  • cerebrospinal fluid leak
  • cerebrospinal fluid leak repair
  • cerebrospinal fluid rhinorrhea
  • empty sella
  • Encephalocele
  • endoscopic sinus surgery
  • intracranial hypertension
  • pseudotumor cerebri
  • skull base defect
  • spontaneous

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Medicine(all)

Cite this

Chaaban, M., Illing, E., Riley, K. O., & Woodworth, B. A. (2014). Spontaneous cerebrospinal fluid leak repair: A five-year prospective evaluation. Laryngoscope, 124(1), 70-75. https://doi.org/10.1002/lary.24160

Spontaneous cerebrospinal fluid leak repair : A five-year prospective evaluation. / Chaaban, Mohamad; Illing, Elisa; Riley, Kristen O.; Woodworth, Bradford A.

In: Laryngoscope, Vol. 124, No. 1, 2014, p. 70-75.

Research output: Contribution to journalArticle

Chaaban, M, Illing, E, Riley, KO & Woodworth, BA 2014, 'Spontaneous cerebrospinal fluid leak repair: A five-year prospective evaluation', Laryngoscope, vol. 124, no. 1, pp. 70-75. https://doi.org/10.1002/lary.24160
Chaaban, Mohamad ; Illing, Elisa ; Riley, Kristen O. ; Woodworth, Bradford A. / Spontaneous cerebrospinal fluid leak repair : A five-year prospective evaluation. In: Laryngoscope. 2014 ; Vol. 124, No. 1. pp. 70-75.
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