Spontaneous recurrent seizure following status epilepticus enhances dentate gyrus neurogenesis

Byung Ho Cha, Cigdem Akman, Diosely C. Silveira, Xianzeng Liu, Gregory L. Holmes

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


It is known that evoked seizures can increase neurogenesis in the dentate gyrus in adult rats. Whether spontaneous seizures occurring after status epilepticus (SE) also results in alterations in neurogenesis is not known. Here, we measured neurogenesis in rats with and without spontaneous seizures following SE. Lithium-pilocarpine was used to induce seizures in postnatal (P) day 20 rats. Spontaneous seizure frequency was assessed 2 months using video monitoring. Rats then received bromodeoxyuridine to label dividing DNA and were sacrificed 24 h later. Animals with spontaneous seizures (n=9) had a modest increase in neurogenesis compared to animals with SE (n=6) and no spontaneous seizures and control rats (n=10). These findings demonstrate that the hippocampus is capable of generating new neurons weeks following SE and further that recurrent seizures enhance the production of new neurons. These alterations in neurogenesis may contribute to ongoing pathological changes week and months following SE.

Original languageEnglish (US)
Pages (from-to)394-397
Number of pages4
JournalBrain and Development
Issue number6
StatePublished - Sep 2004
Externally publishedYes


  • Bromodeoxyuridine
  • Epilepsy
  • Hippocampus
  • Lithium
  • Pilocarpine
  • Seizures

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology


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