Sporotrichosis as a presenting manifestation of hairy cell leukemia

S. Kumar, D. Kumar, W. K. Gourley, J. B. Alperin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

An infectious episode is the presenting manifestation of hairy cell leukemia (HCL) in approximately 30% of cases. Most often this is bacterial and only rare cases of opportunistic fungal infection are described. We report a patient who presented with sporotrichal involvement of multiple cutaneous sites and lymph nodes. The lesions resolved following antifungal therapy, but persisting pancytopenia and splenomegaly necessitated further hematological evaluation. A diagnosis of HCL was suspected based on morphologically characteristic hairy cells in the peripheral blood that contained tartrate resistant acid phosphatase. A bone marrow biopsy specimen had a normocellular marrow with an increase in interstitial lymphoid cells that stained with L26, MB2, and LN2 antibodies. On flow cytometry these cells were positive for the leukocyte common antigen, B cell markers, and the CD11c antigen confirming the diagnosis of HCL. We believe that this is the first report of sporotrichosis infection as a presenting manifestation of HCL.

Original languageEnglish (US)
Pages (from-to)134-137
Number of pages4
JournalAmerican Journal of Hematology
Volume46
Issue number2
DOIs
StatePublished - 1994

Fingerprint

Sporotrichosis
Hairy Cell Leukemia
CD11c Antigens
Bone Marrow
CD45 Antigens
Pancytopenia
Mycoses
Splenomegaly
Differentiation Antigens
Opportunistic Infections
Flow Cytometry
B-Lymphocytes
Lymph Nodes
Lymphocytes
Biopsy
Skin
Antibodies
Infection

Keywords

  • flow cytometry
  • hairy cell leukemia
  • sporotrichosis

ASJC Scopus subject areas

  • Hematology

Cite this

Sporotrichosis as a presenting manifestation of hairy cell leukemia. / Kumar, S.; Kumar, D.; Gourley, W. K.; Alperin, J. B.

In: American Journal of Hematology, Vol. 46, No. 2, 1994, p. 134-137.

Research output: Contribution to journalArticle

Kumar, S. ; Kumar, D. ; Gourley, W. K. ; Alperin, J. B. / Sporotrichosis as a presenting manifestation of hairy cell leukemia. In: American Journal of Hematology. 1994 ; Vol. 46, No. 2. pp. 134-137.
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