Sporotrichosis as a presenting manifestation of hairy cell leukemia

Shimareet Kumar, Dhruv Kumar, William K. Gourley, Jack B. Alperin

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

An infectious episode is the presenting manifestation of hairy cell leukemia (HCL) in approximately 30% of cases. Most often this is bacterial and only rare cases of opportunistic fungal infection are described. We report a patient who presented with sporotrichal involvement of multiple cutaneous sites and lymph nodes. The lesions resolved following antifungal therapy, but persisting pancytopenia and splenomegaly necessitated further hematological evaluation. A diagnosis of HCL was suspected based on morphologically characteristic hairy cells in the peripheral blood that contained tartrate resistant acid phosphatase. A bone marrow biopsy specimen had a normocellular marrow with an increase in interstitial lymphoid cells that stained with L26, MB2, and LN2 antibodies. On flow cytometry these cells were positive for the leukocyte common antigen, B cell markers, and the CD11c antigen confirming the diagnosis of HCL. We believe that this is the first report of sporotrichosis infection as a presenting manifestation of HCL. © 1994 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)134-137
Number of pages4
JournalAmerican Journal of Hematology
Volume46
Issue number2
DOIs
StatePublished - Jun 1994

Keywords

  • flow cytometry
  • hairy cell leukemia
  • sporotrichosis

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Sporotrichosis as a presenting manifestation of hairy cell leukemia'. Together they form a unique fingerprint.

  • Cite this