Sprouting of Aβ fibers into lamina II of the rat dorsal horn in peripheral neuropathy

Helena A. Lekan, Susan M. Carlton, Richard E. Coggeshall

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

Cholera toxin β-subunit conjugated to horseradish peroxidase was used to label the large myelinated (Aβ) fiber input to the dorsal horn in a model of peripheral neuropathy induced by tight ligation of the L5 and L6 spinal nerves. Following induction of neuropathy, Aβ fibers were present in lamina II of the ipsilateral dorsal horn, a region normally devoid of Aβ input. This reorganization of large fiber input to the superficial dorsal horn provides some anatomical basis for sensory changes found in this model of neuropathic pain.

Original languageEnglish (US)
Pages (from-to)147-150
Number of pages4
JournalNeuroscience Letters
Volume208
Issue number3
DOIs
StatePublished - Apr 26 1996

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Keywords

  • Nociception
  • Plasticity
  • Primary afferents
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)

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