Stable xenon versus radiolabeled microsphere cerebral blood flow measurements in baboons

Douglas Dewitt, P. P. Fatouros, A. O. Wist, L. M. Stewart, H. A. Kontos, J. A. Hall, P. R S Kishore, R. L. Keenan, A. Marmarou

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Regional cerebral blood flow was simultaneously determined using the stable xenon computed tomographic and the radioactive microsphere techniques over a wide range of blood flow rates (<10->300 ml/100g/min) in 12 baboons under conditions of normocapnia, hypocapnia, and hypercapnia. A total of 31 pairs of determinations were made. After anesthetic and surgical preparation of the baboons, cerebral blood flow was repeatedly determined using the stable xenon technique during saturation with 50% xenon in oxigen. Concurrently, cerebral blood flow was determined before and during xenon administration using 15-μm microspheres. In Group 1 (n=7), xenon and microsphere determinations were made repeatedly during normocapnia. In Group 2 (n=5), cerebral blood flow was determined using both techniques in each baboon during hypocapnia (PaCO2=20 mm Hg), normocapnia (PaCO2=40 mm Hg), and hypercapnia (PaCO2=60 mm Hg). Xenon and microsphere values in Group 1 were significantly correlated (r=0.69, p<0.01). In Group 2, values from both techniques also correlated closely across all levels of PaCO2 (r=0.92, p<0.001). No significant differences existed between the slopes or y intercepts of the regression lines for either group and the line of identity. Our data indicate that the stable xenon technique yields cerebral blood flow values that correlate well with values determined using radioactive microspheres across a wide range of cerebral blood flow rates.

Original languageEnglish (US)
Pages (from-to)1716-1723
Number of pages8
JournalStroke
Volume20
Issue number12
StatePublished - 1989
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Xenon
Papio
Microspheres
Hypocapnia
Hypercapnia
Regional Blood Flow
Anesthetics

Keywords

  • baboons
  • Cerebral blood flow
  • microspheres
  • xenon

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Dewitt, D., Fatouros, P. P., Wist, A. O., Stewart, L. M., Kontos, H. A., Hall, J. A., ... Marmarou, A. (1989). Stable xenon versus radiolabeled microsphere cerebral blood flow measurements in baboons. Stroke, 20(12), 1716-1723.

Stable xenon versus radiolabeled microsphere cerebral blood flow measurements in baboons. / Dewitt, Douglas; Fatouros, P. P.; Wist, A. O.; Stewart, L. M.; Kontos, H. A.; Hall, J. A.; Kishore, P. R S; Keenan, R. L.; Marmarou, A.

In: Stroke, Vol. 20, No. 12, 1989, p. 1716-1723.

Research output: Contribution to journalArticle

Dewitt, D, Fatouros, PP, Wist, AO, Stewart, LM, Kontos, HA, Hall, JA, Kishore, PRS, Keenan, RL & Marmarou, A 1989, 'Stable xenon versus radiolabeled microsphere cerebral blood flow measurements in baboons', Stroke, vol. 20, no. 12, pp. 1716-1723.
Dewitt D, Fatouros PP, Wist AO, Stewart LM, Kontos HA, Hall JA et al. Stable xenon versus radiolabeled microsphere cerebral blood flow measurements in baboons. Stroke. 1989;20(12):1716-1723.
Dewitt, Douglas ; Fatouros, P. P. ; Wist, A. O. ; Stewart, L. M. ; Kontos, H. A. ; Hall, J. A. ; Kishore, P. R S ; Keenan, R. L. ; Marmarou, A. / Stable xenon versus radiolabeled microsphere cerebral blood flow measurements in baboons. In: Stroke. 1989 ; Vol. 20, No. 12. pp. 1716-1723.
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