Stage migration with sentinel node biopsy in breast cancer

Rakhshanda Layeequr Rahman, Eric Siegel, Cristiano Boneti, Malene Ingram, Julie Kepple, Ronda S. Henry-Tillman, Vicki Klimberg

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Axillary staging provides the single most important piece of prognostic information in breast cancer patients. This retrospective study was performed to document the phenomenon of stage migration. Methods: Of 392 patients, 5 (1%) failed identification of sentinel lymph nodes (SLNs) and therefore underwent axillary lymph node dissection (ALND). Four patients (80%) had metastatic lymph nodes, 302 (77%) patients had negative SLNs, 47 (15%) underwent ALND, 85 (22%) had positive SLNs, 11 (13%) received adjuvant radiation treatment to the axilla, and 74 (87%) underwent completion ALND. Results: The median (quartiles) follow-up period was 29 months (19-46 mo). Twenty of 392 (5%) patients had disease relapse; 2 of which were local (.5%) and the rest were systemic. Earlier relapse was related significantly to lymph node status, tumor grade, and tumor size. SLN-negative patients who did not receive ALND had a relapse rate of 2.3% (6 of 256) compared with 0% in those who were truly negative based on confirmatory ALND. SLN-positive patients who did not receive ALND had a 9% (1 of 11) relapse rate. Discussion: The stage-matched pattern of relapse between SLN biopsy and ALND patients revealed lower relapse rates in SLN biopsy-staged patients, documenting the stage migration phenomenon.

Original languageEnglish (US)
Pages (from-to)491-496
Number of pages6
JournalAmerican Journal of Surgery
Volume197
Issue number4
DOIs
StatePublished - Apr 2009
Externally publishedYes

Fingerprint

Lymph Node Excision
Breast Neoplasms
Biopsy
Recurrence
Sentinel Lymph Node Biopsy
Lymph Nodes
cyhalothrin
Axilla
Neoplasms
Retrospective Studies
Sentinel Lymph Node
Radiation

Keywords

  • Breast cancer
  • Sentinel lymph node

ASJC Scopus subject areas

  • Surgery

Cite this

Layeequr Rahman, R., Siegel, E., Boneti, C., Ingram, M., Kepple, J., Henry-Tillman, R. S., & Klimberg, V. (2009). Stage migration with sentinel node biopsy in breast cancer. American Journal of Surgery, 197(4), 491-496. https://doi.org/10.1016/j.amjsurg.2008.07.052

Stage migration with sentinel node biopsy in breast cancer. / Layeequr Rahman, Rakhshanda; Siegel, Eric; Boneti, Cristiano; Ingram, Malene; Kepple, Julie; Henry-Tillman, Ronda S.; Klimberg, Vicki.

In: American Journal of Surgery, Vol. 197, No. 4, 04.2009, p. 491-496.

Research output: Contribution to journalArticle

Layeequr Rahman, R, Siegel, E, Boneti, C, Ingram, M, Kepple, J, Henry-Tillman, RS & Klimberg, V 2009, 'Stage migration with sentinel node biopsy in breast cancer', American Journal of Surgery, vol. 197, no. 4, pp. 491-496. https://doi.org/10.1016/j.amjsurg.2008.07.052
Layeequr Rahman R, Siegel E, Boneti C, Ingram M, Kepple J, Henry-Tillman RS et al. Stage migration with sentinel node biopsy in breast cancer. American Journal of Surgery. 2009 Apr;197(4):491-496. https://doi.org/10.1016/j.amjsurg.2008.07.052
Layeequr Rahman, Rakhshanda ; Siegel, Eric ; Boneti, Cristiano ; Ingram, Malene ; Kepple, Julie ; Henry-Tillman, Ronda S. ; Klimberg, Vicki. / Stage migration with sentinel node biopsy in breast cancer. In: American Journal of Surgery. 2009 ; Vol. 197, No. 4. pp. 491-496.
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