Standard Uptake Value Predicts Survival in Non-Small Cell Lung Cancer

Ikenna Okereke, Sidhu P. Gangadharan, Michael S. Kent, Saila P. Nicotera, Changyu Shen, Malcolm M. DeCamp

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Integrated [18F]fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) scan is a widely used modality in the evaluation of lung cancer. Our goal was to determine the ability of the standard uptake value (SUV) of the primary tumor (SUV-T) and regional lymph nodes (SUV-N) to predict survival. Methods: From January 2005 through June 2007, 584 consecutive patients undergoing integrated PET-CT scan for suspected lung cancer were studied. Results of integrated PET-CT scans, including the maximum SUV-T and SUV-N, were recorded. A patient was defined as having a positive PET scan if the maximum SUV (T or N) was greater than 2.5. Overall survival was documented from clinical records and the Social Security Death Index. Cox regression analysis was used to evaluate the correlation between SUV and survival. Results: Among patients with a positive PET scan (n = 329), both SUV-T and SUV-N were predictors of survival. As maximum SUV of the primary mass increased, survival decreased (hazard ratio, 1.05; p <0.001). As maximum SUV of locoregional lymph nodes increased, survival also decreased (hazard ratio, 1.06; p <0.001). Furthermore, among patients with no mediastinal disease identified by PET-CT scan, increased SUV-T continued to predict poor survival (hazard ratio, 1.06; p = 0.001). Conclusions: Local and regional maximum SUVs defined by integrated PET-CT scanning have a strong correlation with survival in patients with non-small cell lung cancer. An elevated SUV is known preoperatively and may assist clinicians in stratifying patients at increased overall risk preoperatively.

Original languageEnglish (US)
Pages (from-to)911-916
Number of pages6
JournalAnnals of Thoracic Surgery
Volume88
Issue number3
DOIs
StatePublished - Sep 2009
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Survival
Positron-Emission Tomography
Lung Neoplasms
Lymph Nodes
Mediastinal Diseases
Social Security
Fluorodeoxyglucose F18
Regression Analysis
Positron Emission Tomography Computed Tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Okereke, I., Gangadharan, S. P., Kent, M. S., Nicotera, S. P., Shen, C., & DeCamp, M. M. (2009). Standard Uptake Value Predicts Survival in Non-Small Cell Lung Cancer. Annals of Thoracic Surgery, 88(3), 911-916. https://doi.org/10.1016/j.athoracsur.2009.05.083

Standard Uptake Value Predicts Survival in Non-Small Cell Lung Cancer. / Okereke, Ikenna; Gangadharan, Sidhu P.; Kent, Michael S.; Nicotera, Saila P.; Shen, Changyu; DeCamp, Malcolm M.

In: Annals of Thoracic Surgery, Vol. 88, No. 3, 09.2009, p. 911-916.

Research output: Contribution to journalArticle

Okereke, I, Gangadharan, SP, Kent, MS, Nicotera, SP, Shen, C & DeCamp, MM 2009, 'Standard Uptake Value Predicts Survival in Non-Small Cell Lung Cancer', Annals of Thoracic Surgery, vol. 88, no. 3, pp. 911-916. https://doi.org/10.1016/j.athoracsur.2009.05.083
Okereke, Ikenna ; Gangadharan, Sidhu P. ; Kent, Michael S. ; Nicotera, Saila P. ; Shen, Changyu ; DeCamp, Malcolm M. / Standard Uptake Value Predicts Survival in Non-Small Cell Lung Cancer. In: Annals of Thoracic Surgery. 2009 ; Vol. 88, No. 3. pp. 911-916.
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