Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia

Maria Labandeira-Rey; Florence Couzon; Sandrine Boisset; Eric L. Brown; Michele Bes; Yvonne Benito; Elena M. Barbu; Vanessa Vazquez; Magnus Höök; Jerome Etienne; François Vandenesch; M. Gabriela Bowden

doi:10.1126/science.1137165

Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia

Maria Labandeira-Rey, Florence Couzon, Sandrine Boisset, Eric L. Brown, Michele Bes, Yvonne Benito, Elena M. Barbu, Vanessa Vazquez, Magnus Höök, Jerome Etienne, François Vandenesch, M. Gabriela Bowden

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631 Scopus citations

Abstract

The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often-lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. aureus strains, as well as purified PVL, in a mouse acute pneumonia model Here we show that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell wall-anchored staphylococcal proteins, including the lung inflammatory factor staphylococcal protein A (Spa).

Original language	English (US)
Pages (from-to)	1130-1133
Number of pages	4
Journal	Science
Volume	315
Issue number	5815
DOIs	https://doi.org/10.1126/science.1137165
State	Published - Feb 23 2007
Externally published	Yes

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title = "Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia",

abstract = "The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often-lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. aureus strains, as well as purified PVL, in a mouse acute pneumonia model Here we show that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell wall-anchored staphylococcal proteins, including the lung inflammatory factor staphylococcal protein A (Spa).",

author = "Maria Labandeira-Rey and Florence Couzon and Sandrine Boisset and Brown, {Eric L.} and Michele Bes and Yvonne Benito and Barbu, {Elena M.} and Vanessa Vazquez and Magnus H{\"o}{\"o}k and Jerome Etienne and Fran{\c c}ois Vandenesch and Bowden, {M. Gabriela}",

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doi = "10.1126/science.1137165",

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AU - Labandeira-Rey, Maria

AU - Couzon, Florence

AU - Boisset, Sandrine

AU - Brown, Eric L.

AU - Bes, Michele

AU - Benito, Yvonne

AU - Barbu, Elena M.

AU - Vazquez, Vanessa

AU - Höök, Magnus

AU - Etienne, Jerome

AU - Vandenesch, François

AU - Bowden, M. Gabriela

PY - 2007/2/23

Y1 - 2007/2/23

N2 - The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often-lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. aureus strains, as well as purified PVL, in a mouse acute pneumonia model Here we show that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell wall-anchored staphylococcal proteins, including the lung inflammatory factor staphylococcal protein A (Spa).

AB - The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often-lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. aureus strains, as well as purified PVL, in a mouse acute pneumonia model Here we show that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell wall-anchored staphylococcal proteins, including the lung inflammatory factor staphylococcal protein A (Spa).

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Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia

Abstract

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