Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation

Kevin A. Murach, Christopher S. Fry, Tyler J. Kirby, Janna R. Jackson, Jonah D. Lee, Sarah H. White, Esther E. Dupont-Versteegden, John J. McCarthy, Charlotte A. Peterson

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy.

Original languageEnglish (US)
Pages (from-to)26-38
Number of pages13
JournalPhysiology
Volume33
Issue number1
DOIs
StatePublished - Jan 2018

ASJC Scopus subject areas

  • Physiology

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    Murach, K. A., Fry, C. S., Kirby, T. J., Jackson, J. R., Lee, J. D., White, S. H., Dupont-Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2018). Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation. Physiology, 33(1), 26-38. https://doi.org/10.1152/physiol.00019.2017