Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation

Kevin A. Murach, Christopher S. Fry, Tyler J. Kirby, Janna R. Jackson, Jonah D. Lee, Sarah H. White, Esther E. Dupont-Versteegden, John J. McCarthy, Charlotte A. Peterson

    Research output: Contribution to journalReview articlepeer-review

    47 Scopus citations

    Abstract

    Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy.

    Original languageEnglish (US)
    Pages (from-to)26-38
    Number of pages13
    JournalPhysiology
    Volume33
    Issue number1
    DOIs
    StatePublished - Jan 2018

    ASJC Scopus subject areas

    • Physiology

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