Status of vaccine research and development of vaccines for Nipah virus

Benjamin A. Satterfield, Brian E. Dawes, Gregg Milligan

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Nipah virus (NiV) is a highly pathogenic, recently emerged paramyxovirus that has been responsible for sporadic outbreaks of respiratory and encephalitic disease in Southeast Asia. High case fatality rates have also been associated with recent outbreaks in Malaysia and Bangladesh. Although over two billion people currently live in regions in which NiV is endemic or in which the Pteropus fruit bat reservoir is commonly found, there is no approved vaccine to protect against NiV disease. This report examines the feasibility and current efforts to develop a NiV vaccine including potential hurdles for technical and regulatory assessment of candidate vaccines and the likelihood for financing.

Original languageEnglish (US)
Pages (from-to)2971-2975
Number of pages5
JournalVaccine
Volume34
Issue number26
DOIs
StatePublished - Jun 3 2016

Keywords

  • Live attenuated vaccine
  • Nipah virus
  • Soluble G protein
  • Subunit vaccine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

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