Stereochemical analysis of deuterated alkyl chains by charge-remote fragmentations of protonated parent ions

Kangling Zhang, Stephane Bouchonnet, Scott V. Serafin, Thomas Hellman Morton

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

MH+ ions from sec-alkyl m-dimethylamino ethers have been studied by MS/MS using chemical ionization (CI) and electrospray ionization (ESI). Collisionally activated dissociation (CAD) of MH+ from the vicinally perdeuterated 3-hexyl ether, CH3CD2CHOArCD2CH2CH3, shows that alkene expulsion is >96% regioselective, yielding m/z 139 and m/z 124 fragment ions. The fact that alkene elimination is not 100% regioselective (but gives about 3% m/z 138) is attributed to a small amount of ion-neutral complex formation. CAD of MH+ ions from vicinally monodeuterated ethers (the 3-hexyl-4-d1 ether (1) and the sec-butyl-3-d1 ether (2)) demonstrates that the erythro and threo diastereomers give significantly different m/z 139:m/z 138 fragment ion intensity ratios. These intensity ratios are sufficiently reproducible that they can be used to quantitate the proportions of erythro and threo in mixtures. DFT calculations show substantial differences between the 4-center transition states for charge-remote elimination vs. alkene elimination from a neutral precursor.

Original languageEnglish (US)
Pages (from-to)175-189
Number of pages15
JournalInternational Journal of Mass Spectrometry
Volume227
Issue number1
DOIs
StatePublished - May 15 2003
Externally publishedYes

Fingerprint

Ethers
ethers
fragmentation
Ions
Alkenes
Ether
alkenes
Olefins
elimination
ions
fragments
dissociation
ionization
Electrospray ionization
expulsion
Discrete Fourier transforms
Ionization
proportion

Keywords

  • 4-Center transition state
  • Density functional theory
  • Dissociative resonance structures
  • Keto-enol tautomerization
  • Vicinal elimination
  • Zwitterion

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Spectroscopy

Cite this

Stereochemical analysis of deuterated alkyl chains by charge-remote fragmentations of protonated parent ions. / Zhang, Kangling; Bouchonnet, Stephane; Serafin, Scott V.; Morton, Thomas Hellman.

In: International Journal of Mass Spectrometry, Vol. 227, No. 1, 15.05.2003, p. 175-189.

Research output: Contribution to journalArticle

Zhang, Kangling ; Bouchonnet, Stephane ; Serafin, Scott V. ; Morton, Thomas Hellman. / Stereochemical analysis of deuterated alkyl chains by charge-remote fragmentations of protonated parent ions. In: International Journal of Mass Spectrometry. 2003 ; Vol. 227, No. 1. pp. 175-189.
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