TY - JOUR
T1 - Still SDAPing Along
T2 - 20 Years of the Structural Database of Allergenic Proteins
AU - Schein, Catherine H.
AU - Negi, Surendra S.
AU - Braun, Werner
N1 - Funding Information:
SDAP was originally designed and compiled by Drs. Ovidiu Ivanciuc and WB and is presently maintained by SN. Three dimensional models were originally generated by Numan S. Oezguen and Trevor D. Power and are currently being updated by SN. The PD search began with the Ph.D. thesis work of Venkatarajan A. Mathura. The D-graph program was written by Benjamin A. Braun, Ph.D., with physics advice from WB and validated for use with protein sequences of allergens and viruses by CHS. We thank all our collaborators over the 20 years of SDAP's existence as well as those using its tools in research and regulatory matters.
Funding Information:
SDAP was originally funded by a Research Development Grant (#2535-01) from the John Sealy Memorial Endowment Fund for Biomedical Research, grants from the US-Food and Drug Administration (FD-U-002249), and the Texas Higher Education Coordinating Board (ATP grant 004952-0036-2003) to WB. Our work with allergenic proteins and SDAP upkeep has been supported by grants from the U.S. Environmental Protection Agency under STAR Research Assistance Agreements (RD-833137, RD-834823-01 to WB, RE-83406601 to CHS), the US Department of Agriculture (ARS 58-6435-9-40 to CHS), the National Institute of Health (R01 AI 064913 to WB, 1R01AI165866-01 to Stephen Dreskin; subcontract to CHS), and funding for this article was provided by the Margaret Maccallum Gage and Tracy Davis Gage Professorship in Biochemistry and Allergies to WB.
Publisher Copyright:
Copyright © 2022 Schein, Negi and Braun.
PY - 2022
Y1 - 2022
N2 - The introduction of plant extracts to mitigate the symptoms of “hay fever”, about a century ago, led to discoveries beginning sixty years ago on determining the sequences and eventually structures of allergenic proteins. As more proteins were cloned, there was a need to rapidly identify and categorize those with significant similarity to known allergens. The Structural Database of Allergenic Proteins (SDAP) was created at the beginning of the 21st century as the first cross-referenced website to allow rapid overview of the structures and sequences of allergenic proteins. SDAP provides a way to identify sequence and functional similarities between these proteins, despite the complex nomenclature system based on the Latin names of their different sources. A rapid FASTA search simplifies grouping allergens from the same structural or functional family. SDAP also provides an overview of the rapidly expanding literature on the sequence, structure and epitopes of allergenic proteins and a way to estimate the potential allergenicity of novel proteins based on rules provided by the IUIS. Twenty years and a pandemic later, the list of allergenic proteins and their attributes continues to grow. SDAP is expanding and improving to allow rapid access to all this information.
AB - The introduction of plant extracts to mitigate the symptoms of “hay fever”, about a century ago, led to discoveries beginning sixty years ago on determining the sequences and eventually structures of allergenic proteins. As more proteins were cloned, there was a need to rapidly identify and categorize those with significant similarity to known allergens. The Structural Database of Allergenic Proteins (SDAP) was created at the beginning of the 21st century as the first cross-referenced website to allow rapid overview of the structures and sequences of allergenic proteins. SDAP provides a way to identify sequence and functional similarities between these proteins, despite the complex nomenclature system based on the Latin names of their different sources. A rapid FASTA search simplifies grouping allergens from the same structural or functional family. SDAP also provides an overview of the rapidly expanding literature on the sequence, structure and epitopes of allergenic proteins and a way to estimate the potential allergenicity of novel proteins based on rules provided by the IUIS. Twenty years and a pandemic later, the list of allergenic proteins and their attributes continues to grow. SDAP is expanding and improving to allow rapid access to all this information.
KW - allergenic protein nomenclature
KW - component resolved extracts
KW - history of allergen studies
KW - IgE epitopes
KW - peanut and nut allergens
KW - physicochemical property scale
KW - property distance scale
KW - sequence and structure
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U2 - 10.3389/falgy.2022.863172
DO - 10.3389/falgy.2022.863172
M3 - Article
AN - SCOPUS:85159926771
SN - 2673-6101
VL - 3
JO - Frontiers in Allergy
JF - Frontiers in Allergy
M1 - 863172
ER -