Stimulation of calcitonin secretion in the pig by calcitonin gene-related peptide

C. W. Cooper, M. B. McPherson, P. K. Seitz, G. H. Greeley, S. K. Abbas, D. W. Pickard, A. D. Care

    Research output: Contribution to journalArticle

    4 Scopus citations

    Abstract

    Pig thyroid glands were surgically isolated in situ and perfused with autologous blood to which was added known concentrations of calcitonin gene-related peptide (αCGRP). When thyroids were perfused with measured concentrations of CGRP within the range of 0.6-600 nM, the secretion rate of calcitonin (CT) was stimulated while the release of T3, T4, and somatostatin remained unchanged. Specific binding of 125I-CGRP to pig thyroid plasma membranes was demonstrated, and binding was inhibited by unlabelled CGRP but not by CT or by other peptides unrelated structurally to CGRP. The findings indicate that the pig thyroid gland contains plasma membrane binding sites for CGRP and that CGRP is capable of stimulating the secretion of CT.

    Original languageEnglish (US)
    Pages (from-to)73-79
    Number of pages7
    JournalBone and Mineral
    Volume12
    Issue number2
    DOIs
    StatePublished - Feb 1991

    Keywords

    • Calcitonin
    • Calcitonin gene-related peptide

    ASJC Scopus subject areas

    • Surgery
    • Biochemistry
    • Endocrinology

    Fingerprint Dive into the research topics of 'Stimulation of calcitonin secretion in the pig by calcitonin gene-related peptide'. Together they form a unique fingerprint.

  • Cite this

    Cooper, C. W., McPherson, M. B., Seitz, P. K., Greeley, G. H., Abbas, S. K., Pickard, D. W., & Care, A. D. (1991). Stimulation of calcitonin secretion in the pig by calcitonin gene-related peptide. Bone and Mineral, 12(2), 73-79. https://doi.org/10.1016/0169-6009(91)90036-Y