Stimulation of calcitonin secretion in the pig by calcitonin gene-related peptide

C. W. Cooper, M. B. McPherson, P. K. Seitz, G. H. Greeley, S. K. Abbas, D. W. Pickard, A. D. Care

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Pig thyroid glands were surgically isolated in situ and perfused with autologous blood to which was added known concentrations of calcitonin gene-related peptide (αCGRP). When thyroids were perfused with measured concentrations of CGRP within the range of 0.6-600 nM, the secretion rate of calcitonin (CT) was stimulated while the release of T3, T4, and somatostatin remained unchanged. Specific binding of 125I-CGRP to pig thyroid plasma membranes was demonstrated, and binding was inhibited by unlabelled CGRP but not by CT or by other peptides unrelated structurally to CGRP. The findings indicate that the pig thyroid gland contains plasma membrane binding sites for CGRP and that CGRP is capable of stimulating the secretion of CT.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalBone and Mineral
Volume12
Issue number2
DOIs
StatePublished - 1991

Fingerprint

Calcitonin Gene-Related Peptide
Calcitonin
Swine
Thyroid Gland
Cell membranes
Cell Membrane
Somatostatin
Blood
Binding Sites
Peptides

Keywords

  • Calcitonin
  • Calcitonin gene-related peptide

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Surgery

Cite this

Cooper, C. W., McPherson, M. B., Seitz, P. K., Greeley, G. H., Abbas, S. K., Pickard, D. W., & Care, A. D. (1991). Stimulation of calcitonin secretion in the pig by calcitonin gene-related peptide. Bone and Mineral, 12(2), 73-79. https://doi.org/10.1016/0169-6009(91)90036-Y

Stimulation of calcitonin secretion in the pig by calcitonin gene-related peptide. / Cooper, C. W.; McPherson, M. B.; Seitz, P. K.; Greeley, G. H.; Abbas, S. K.; Pickard, D. W.; Care, A. D.

In: Bone and Mineral, Vol. 12, No. 2, 1991, p. 73-79.

Research output: Contribution to journalArticle

Cooper, CW, McPherson, MB, Seitz, PK, Greeley, GH, Abbas, SK, Pickard, DW & Care, AD 1991, 'Stimulation of calcitonin secretion in the pig by calcitonin gene-related peptide', Bone and Mineral, vol. 12, no. 2, pp. 73-79. https://doi.org/10.1016/0169-6009(91)90036-Y
Cooper CW, McPherson MB, Seitz PK, Greeley GH, Abbas SK, Pickard DW et al. Stimulation of calcitonin secretion in the pig by calcitonin gene-related peptide. Bone and Mineral. 1991;12(2):73-79. https://doi.org/10.1016/0169-6009(91)90036-Y
Cooper, C. W. ; McPherson, M. B. ; Seitz, P. K. ; Greeley, G. H. ; Abbas, S. K. ; Pickard, D. W. ; Care, A. D. / Stimulation of calcitonin secretion in the pig by calcitonin gene-related peptide. In: Bone and Mineral. 1991 ; Vol. 12, No. 2. pp. 73-79.
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