Stimulation of nerve growth factor receptors in PC12 by acetyl-l-carnitine

Giulio Taglialatela; Luciano Angelucci; Maria Teresa Ramacci; Karin Werrbach-Perez; George R. Jackson; Jose R Perez-Polo

doi:10.1016/0006-2952(92)90452-O

Stimulation of nerve growth factor receptors in PC12 by acetyl-l-carnitine

Giulio Taglialatela, Luciano Angelucci, Maria Teresa Ramacci, Karin Werrbach-Perez, George R. Jackson, Jose R Perez-Polo

Neurology

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Acetyl-l-carnitine (ALCAR) prevents some deficits associated with aging in the central nervous system (CNS), such as the aged-related reduction of nerve growth factor (NGF) binding. The aim of this study was to ascertain whether ALCAR could affect the expression of an NGF receptor (p75^NGFR) Treatment of PC12 cells with ALCAR increased equilibrium binding of ¹²⁵I-NGF. ALCAR treatment also increased the amount of immunoprecipitable p75^NGFR from PC12 cells. Lastly, the level of p75^NGFR messenger RNA (mRNA) in PC12 was increased following ALCAR treatment. These results are in agreement with the hypothesis that there is a direct action of ALCAR on p75^NGFR expression in aged rodent CNS.

Original language	English (US)
Pages (from-to)	577-585
Number of pages	9
Journal	Biochemical Pharmacology
Volume	44
Issue number	3
DOIs	https://doi.org/10.1016/0006-2952(92)90452-O
State	Published - Aug 4 1992

ASJC Scopus subject areas

Biochemistry
Pharmacology

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10.1016/0006-2952(92)90452-O

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title = "Stimulation of nerve growth factor receptors in PC12 by acetyl-l-carnitine",

abstract = "Acetyl-l-carnitine (ALCAR) prevents some deficits associated with aging in the central nervous system (CNS), such as the aged-related reduction of nerve growth factor (NGF) binding. The aim of this study was to ascertain whether ALCAR could affect the expression of an NGF receptor (p75NGFR) Treatment of PC12 cells with ALCAR increased equilibrium binding of 125I-NGF. ALCAR treatment also increased the amount of immunoprecipitable p75NGFR from PC12 cells. Lastly, the level of p75NGFR messenger RNA (mRNA) in PC12 was increased following ALCAR treatment. These results are in agreement with the hypothesis that there is a direct action of ALCAR on p75NGFR expression in aged rodent CNS.",

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T1 - Stimulation of nerve growth factor receptors in PC12 by acetyl-l-carnitine

AU - Taglialatela, Giulio

AU - Angelucci, Luciano

AU - Ramacci, Maria Teresa

AU - Werrbach-Perez, Karin

AU - Jackson, George R.

AU - Perez-Polo, Jose R

PY - 1992/8/4

Y1 - 1992/8/4

N2 - Acetyl-l-carnitine (ALCAR) prevents some deficits associated with aging in the central nervous system (CNS), such as the aged-related reduction of nerve growth factor (NGF) binding. The aim of this study was to ascertain whether ALCAR could affect the expression of an NGF receptor (p75NGFR) Treatment of PC12 cells with ALCAR increased equilibrium binding of 125I-NGF. ALCAR treatment also increased the amount of immunoprecipitable p75NGFR from PC12 cells. Lastly, the level of p75NGFR messenger RNA (mRNA) in PC12 was increased following ALCAR treatment. These results are in agreement with the hypothesis that there is a direct action of ALCAR on p75NGFR expression in aged rodent CNS.

AB - Acetyl-l-carnitine (ALCAR) prevents some deficits associated with aging in the central nervous system (CNS), such as the aged-related reduction of nerve growth factor (NGF) binding. The aim of this study was to ascertain whether ALCAR could affect the expression of an NGF receptor (p75NGFR) Treatment of PC12 cells with ALCAR increased equilibrium binding of 125I-NGF. ALCAR treatment also increased the amount of immunoprecipitable p75NGFR from PC12 cells. Lastly, the level of p75NGFR messenger RNA (mRNA) in PC12 was increased following ALCAR treatment. These results are in agreement with the hypothesis that there is a direct action of ALCAR on p75NGFR expression in aged rodent CNS.

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Stimulation of nerve growth factor receptors in PC12 by acetyl-l-carnitine

Abstract

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