Stimulation of neural cells by lateral currents in conductive layer-by-layer films of single-walled carbon nanotubes

Muhammed K. Gheith, Todd C. Pappas, Anton V. Liopo, Vladimir A. Sinani, Bong Sup Shim, Massoud Motamedi, James P. Wicksted, Nicholas A. Kotov

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

The electrophysiological activity taking place through the membrane of neuronlike NG108-15 cells upon stimulation through the single walled carbon nanotube (SWNT) coatings was investigated. A special substrate was designed in order to obtain electrophysiological measurements on the communication between neuron cells and SWNT LBL films. The successful electrical stimulation of NG108-15 cells depends on the ability of the cells to attach to the surface of nanotube films. Electrophysiological measurements were conducted using a voltage/patch clamp technique. Cells were voltage clamped using single patch electrodes in the whole-cell mode. The potential between the pipette electrode and the reference electrode in the bath was held at -60 mV. It was observed that SWNt can be incorporated into LBL multilayers with sufficiently high electrical conductivity to electrically stimulate excitable neuron cells.

Original languageEnglish (US)
Pages (from-to)2975-2979
Number of pages5
JournalAdvanced Materials
Volume18
Issue number22
DOIs
StatePublished - Nov 17 2006

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Single-walled carbon nanotubes (SWCN)
Electrodes
Neurons
Clamping devices
Electric potential
Nanotubes
Multilayers
Membranes
Coatings
Communication
Substrates

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Stimulation of neural cells by lateral currents in conductive layer-by-layer films of single-walled carbon nanotubes. / Gheith, Muhammed K.; Pappas, Todd C.; Liopo, Anton V.; Sinani, Vladimir A.; Shim, Bong Sup; Motamedi, Massoud; Wicksted, James P.; Kotov, Nicholas A.

In: Advanced Materials, Vol. 18, No. 22, 17.11.2006, p. 2975-2979.

Research output: Contribution to journalArticle

Gheith, MK, Pappas, TC, Liopo, AV, Sinani, VA, Shim, BS, Motamedi, M, Wicksted, JP & Kotov, NA 2006, 'Stimulation of neural cells by lateral currents in conductive layer-by-layer films of single-walled carbon nanotubes', Advanced Materials, vol. 18, no. 22, pp. 2975-2979. https://doi.org/10.1002/adma.200600878
Gheith, Muhammed K. ; Pappas, Todd C. ; Liopo, Anton V. ; Sinani, Vladimir A. ; Shim, Bong Sup ; Motamedi, Massoud ; Wicksted, James P. ; Kotov, Nicholas A. / Stimulation of neural cells by lateral currents in conductive layer-by-layer films of single-walled carbon nanotubes. In: Advanced Materials. 2006 ; Vol. 18, No. 22. pp. 2975-2979.
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