Stimulation of neural cells by lateral currents in conductive layer-by-layer films of single-walled carbon nanotubes

Muhammed K. Gheith, Todd C. Pappas, Anton V. Liopo, Vladimir A. Sinani, Bong Sup Shim, Massoud Motamedi, James P. Wicksted, Nicholas A. Kotov

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Abstract

The electrophysiological activity taking place through the membrane of neuronlike NG108-15 cells upon stimulation through the single walled carbon nanotube (SWNT) coatings was investigated. A special substrate was designed in order to obtain electrophysiological measurements on the communication between neuron cells and SWNT LBL films. The successful electrical stimulation of NG108-15 cells depends on the ability of the cells to attach to the surface of nanotube films. Electrophysiological measurements were conducted using a voltage/patch clamp technique. Cells were voltage clamped using single patch electrodes in the whole-cell mode. The potential between the pipette electrode and the reference electrode in the bath was held at -60 mV. It was observed that SWNt can be incorporated into LBL multilayers with sufficiently high electrical conductivity to electrically stimulate excitable neuron cells.

Original languageEnglish (US)
Pages (from-to)2975-2979
Number of pages5
JournalAdvanced Materials
Volume18
Issue number22
DOIs
StatePublished - Nov 17 2006

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ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Gheith, M. K., Pappas, T. C., Liopo, A. V., Sinani, V. A., Shim, B. S., Motamedi, M., Wicksted, J. P., & Kotov, N. A. (2006). Stimulation of neural cells by lateral currents in conductive layer-by-layer films of single-walled carbon nanotubes. Advanced Materials, 18(22), 2975-2979. https://doi.org/10.1002/adma.200600878