Stimulatory effect of brussels sprouts and cabbage on human drug metabolism

E. J. Pantuck, C. B. Pantuck, W. A. Garland, B. H. Min, L. W. Wattenberg, K. E. Anderson, A. Kappas, A. H. Conney

Research output: Contribution to journalArticle

207 Scopus citations

Abstract

Ten healthy volunteers were fed (1) a control diet for 10 days, (2) the same control diet for 3 additional days and a brussels sprouts and cabbage-containing diet for the next 7 days, and (3) the control diet for the 10 subsequent days. Antipyrine and phenacetin were administered orally before breakfast on days 7 and 10, respectively, of each dietary, regimen. During the test diet period the mean plasma half-life of antipyrine decreased 13% and the mean metabolic clearance rate increased 11%. While small, these changes were statistically significant, indicating a stimulatory, effect of cabbage and brussels sprouts on antipyrine metabolism. The values returned to control levels during the second control diet period. During the test diet period the mean plasma concentration of phenacetin was decreased by 34% to 67% at each time interval from 0.5 to 7 hr after phenacetin administration, and the mean plasma concentration of total (conjugated plus unconjugated) N-acetyl-p-aminophenol (APAP), phenacetin's major metabolite, was increased from 0.5 to 3 hr after phenacetin administration. The concentrations of phenacetin and APAP returned toward control values during the second control diet period. The mean plasma half-life of phenacetin was not influenced by the dietary changes. These results suggest that the test diet enhanced the metabolism of phenacetin in the gastrointestinal tract and/or during its first pass through the liver. Feeding the test diet increased the mean ratio of conjugated APAP to unconjugated APAP observed in plasma at each time interval from 0.5 to 7 hr after phenacetin administration, suggesting that the diet enhanced the conjugation of APAP.

Original languageEnglish (US)
Pages (from-to)88-95
Number of pages8
JournalClinical Pharmacology and Therapeutics
Volume25
Issue number1
DOIs
StatePublished - Jan 1979

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Stimulatory effect of brussels sprouts and cabbage on human drug metabolism'. Together they form a unique fingerprint.

  • Cite this

    Pantuck, E. J., Pantuck, C. B., Garland, W. A., Min, B. H., Wattenberg, L. W., Anderson, K. E., Kappas, A., & Conney, A. H. (1979). Stimulatory effect of brussels sprouts and cabbage on human drug metabolism. Clinical Pharmacology and Therapeutics, 25(1), 88-95. https://doi.org/10.1002/cpt197925188