Abstract
Basal whole body lipid kinetics were evaluated in nine endurance-trained cyclists and 10 untrained healthy controls. The rate of appearance (Ra) of glycerol (an index of whole body lipolysis), the Ra of palmitate (an index of fatty acid release), and the rate of triglyceride-fatty acid cycling (reesterification of fatty acids released during lipolysis) were determined by infusing [2H5]glycerol and [2H2]palmitate in conjunction with indirect calorimetry. All subjects were studied while they were at rest after fasting overnight. Glycerol Ra and free fatty acid Ra in the athletes (7.33 ± 0.68 and 14.88 ± 1.35 μmol · kg-1 · min-1, respectively) were two- to threefold higher than the values in untrained control subjects (2.53 ± 0.15 and 7.64 ± 0.92 μmol · kg-1 · min-1, respectively; P < 0.02). The total rate of triglyceride-fatty acid cycling was approximately fourfold higher in the athletes (16.86 ± 2.07 μmol · kg-1 · min-1) than in the control subjects (3.91 ± 0.36 μmol · kg-1 · min-1). Plasma concentrations of insulin and catecholamines, hormones that regulate whole body lipid kinetics, were the same in both groups. We conclude that resting basal lipid kinetics are markedly increased in athletes involved in strenuous endurance training and that this enhances the potential for increasing fatty acid oxidation rapidly at the onset of exercise.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 108-113 |
| Number of pages | 6 |
| Journal | Journal of Applied Physiology |
| Volume | 75 |
| Issue number | 1 |
| State | Published - 1993 |
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Keywords
- lipid metabolism
- mass spectrometry
- stable isotopes
ASJC Scopus subject areas
- Endocrinology
- Physiology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Strenuous endurance training increases lipolysis and triglyceride-fatty acid cycling at rest. / Romijn, J. A.; Klein, S.; Coyle, E. F.; Sidossis, L. S.; Wolfe, R. R.
In: Journal of Applied Physiology, Vol. 75, No. 1, 1993, p. 108-113.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Strenuous endurance training increases lipolysis and triglyceride-fatty acid cycling at rest
AU - Romijn, J. A.
AU - Klein, S.
AU - Coyle, E. F.
AU - Sidossis, L. S.
AU - Wolfe, R. R.
PY - 1993
Y1 - 1993
N2 - Basal whole body lipid kinetics were evaluated in nine endurance-trained cyclists and 10 untrained healthy controls. The rate of appearance (Ra) of glycerol (an index of whole body lipolysis), the Ra of palmitate (an index of fatty acid release), and the rate of triglyceride-fatty acid cycling (reesterification of fatty acids released during lipolysis) were determined by infusing [2H5]glycerol and [2H2]palmitate in conjunction with indirect calorimetry. All subjects were studied while they were at rest after fasting overnight. Glycerol Ra and free fatty acid Ra in the athletes (7.33 ± 0.68 and 14.88 ± 1.35 μmol · kg-1 · min-1, respectively) were two- to threefold higher than the values in untrained control subjects (2.53 ± 0.15 and 7.64 ± 0.92 μmol · kg-1 · min-1, respectively; P < 0.02). The total rate of triglyceride-fatty acid cycling was approximately fourfold higher in the athletes (16.86 ± 2.07 μmol · kg-1 · min-1) than in the control subjects (3.91 ± 0.36 μmol · kg-1 · min-1). Plasma concentrations of insulin and catecholamines, hormones that regulate whole body lipid kinetics, were the same in both groups. We conclude that resting basal lipid kinetics are markedly increased in athletes involved in strenuous endurance training and that this enhances the potential for increasing fatty acid oxidation rapidly at the onset of exercise.
AB - Basal whole body lipid kinetics were evaluated in nine endurance-trained cyclists and 10 untrained healthy controls. The rate of appearance (Ra) of glycerol (an index of whole body lipolysis), the Ra of palmitate (an index of fatty acid release), and the rate of triglyceride-fatty acid cycling (reesterification of fatty acids released during lipolysis) were determined by infusing [2H5]glycerol and [2H2]palmitate in conjunction with indirect calorimetry. All subjects were studied while they were at rest after fasting overnight. Glycerol Ra and free fatty acid Ra in the athletes (7.33 ± 0.68 and 14.88 ± 1.35 μmol · kg-1 · min-1, respectively) were two- to threefold higher than the values in untrained control subjects (2.53 ± 0.15 and 7.64 ± 0.92 μmol · kg-1 · min-1, respectively; P < 0.02). The total rate of triglyceride-fatty acid cycling was approximately fourfold higher in the athletes (16.86 ± 2.07 μmol · kg-1 · min-1) than in the control subjects (3.91 ± 0.36 μmol · kg-1 · min-1). Plasma concentrations of insulin and catecholamines, hormones that regulate whole body lipid kinetics, were the same in both groups. We conclude that resting basal lipid kinetics are markedly increased in athletes involved in strenuous endurance training and that this enhances the potential for increasing fatty acid oxidation rapidly at the onset of exercise.
KW - lipid metabolism
KW - mass spectrometry
KW - stable isotopes
UR - http://www.scopus.com/inward/record.url?scp=0027304679&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027304679&partnerID=8YFLogxK
M3 - Article
C2 - 8376256
AN - SCOPUS:0027304679
VL - 75
SP - 108
EP - 113
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 1
ER -