Stress and nicotine during adolescence disrupts adult hippocampal-dependent learning and alters stress reactivity

Erica Holliday, Sheree F. Logue, Chicora Oliver, Debra A. Bangasser, Thomas J. Gould

Research output: Contribution to journalArticle

Abstract

Adolescence represents increased susceptibility to stress that increases risk for nicotine dependence. The present study examined the interactive effects of brief exposure to stress (shipping/transportation or experimentally induced) and chronic nicotine during adolescence on cognitive function and stress reactivity in adulthood. Adolescent (P31), but not young adult (P47), C57BL/6J mice had higher levels of corticosterone after shipping vs mice bred onsite. Shipped preadolescent (P23) and adolescent (P38) mice, but not those bred onsite, exposed to nicotine showed deficits in contextual fear learning when tested in adulthood. Adult learning deficits were replicated in adolescent mice bred onsite, exposed to experimentally induced stress, and administered chronic nicotine. Stress and nicotine during adolescence resulted in higher expression of hippocampal glucocorticoid receptors and corticotropin-releasing factor receptors and blunted restraint induced CORT release in adulthood. Importantly, studies examining adolescent behavior in mice should consider stress influences outcomes.

Original languageEnglish (US)
Article numbere12769
JournalAddiction Biology
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Fingerprint

Nicotine
Learning
Corticotropin-Releasing Hormone Receptors
Tobacco Use Disorder
Adolescent Behavior
Glucocorticoid Receptors
Corticosterone
Inbred C57BL Mouse
Cognition
Fear
Young Adult

Keywords

  • adolescence
  • contextual fear
  • corticosterone
  • hippocampus
  • nicotine
  • stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health

Cite this

Stress and nicotine during adolescence disrupts adult hippocampal-dependent learning and alters stress reactivity. / Holliday, Erica; Logue, Sheree F.; Oliver, Chicora; Bangasser, Debra A.; Gould, Thomas J.

In: Addiction Biology, 01.01.2019.

Research output: Contribution to journalArticle

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