Stretchy proteins on stretchy substrates: The important elements of integrin-mediated rigidity sensing

Simon W. Moore; Pere Roca-Cusachs; Michael P. Sheetz

doi:10.1016/j.devcel.2010.07.018

Stretchy proteins on stretchy substrates: The important elements of integrin-mediated rigidity sensing

Simon W. Moore, Pere Roca-Cusachs, Michael P. Sheetz

Research output: Contribution to journal › Review article › peer-review

331 Scopus citations

Abstract

Matrix and tissue rigidity guides many cellular processes, including the differentiation of stem cells and the migration of cells in health and disease. Cells actively and transiently test rigidity using mechanisms limited by inherent physical parameters that include the strength of extracellular attachments, the pulling capacity on these attachments, and the sensitivity of the mechanotransduction system. Here, we focus on rigidity sensing mediated through the integrin family of extracellular matrix receptors and linked proteins and discuss the evidence supporting these proteins as mechanosensors.

Original language	English (US)
Pages (from-to)	194-206
Number of pages	13
Journal	Developmental cell
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2010.07.018
State	Published - Aug 2010
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2010.07.018

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abstract = "Matrix and tissue rigidity guides many cellular processes, including the differentiation of stem cells and the migration of cells in health and disease. Cells actively and transiently test rigidity using mechanisms limited by inherent physical parameters that include the strength of extracellular attachments, the pulling capacity on these attachments, and the sensitivity of the mechanotransduction system. Here, we focus on rigidity sensing mediated through the integrin family of extracellular matrix receptors and linked proteins and discuss the evidence supporting these proteins as mechanosensors.",

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AU - Sheetz, Michael P.

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AB - Matrix and tissue rigidity guides many cellular processes, including the differentiation of stem cells and the migration of cells in health and disease. Cells actively and transiently test rigidity using mechanisms limited by inherent physical parameters that include the strength of extracellular attachments, the pulling capacity on these attachments, and the sensitivity of the mechanotransduction system. Here, we focus on rigidity sensing mediated through the integrin family of extracellular matrix receptors and linked proteins and discuss the evidence supporting these proteins as mechanosensors.

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Stretchy proteins on stretchy substrates: The important elements of integrin-mediated rigidity sensing

Abstract

ASJC Scopus subject areas

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