Stretchy proteins on stretchy substrates: The important elements of integrin-mediated rigidity sensing

Simon W. Moore, Pere Roca-Cusachs, Michael P. Sheetz

Research output: Contribution to journalReview articlepeer-review

269 Scopus citations

Abstract

Matrix and tissue rigidity guides many cellular processes, including the differentiation of stem cells and the migration of cells in health and disease. Cells actively and transiently test rigidity using mechanisms limited by inherent physical parameters that include the strength of extracellular attachments, the pulling capacity on these attachments, and the sensitivity of the mechanotransduction system. Here, we focus on rigidity sensing mediated through the integrin family of extracellular matrix receptors and linked proteins and discuss the evidence supporting these proteins as mechanosensors.

Original languageEnglish (US)
Pages (from-to)194-206
Number of pages13
JournalDevelopmental cell
Volume19
Issue number2
DOIs
StatePublished - Aug 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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