Striated-for-smooth muscle replacement in the developing mouse esophagus

Mark Baguma-Nibasheka, Anna Fracassi, Willard J. Costain, Sandra Moreno, Boris Kablar

Research output: Contribution to journalReview article

Abstract

The esophagus is a muscular tube which transports swallowed content from the oral cavity and the pharynx to the stomach. Early in mouse development, an entire layer of the esophagus, the muscularis externa, consists of differentiated smooth muscle cells. Starting shortly after mid-gestation till about two weeks after birth, the muscularis externa almost entirely consists of striated muscle. This proximal-to-distal replacement of smooth muscle by the striated muscle depends on a number of factors. To identify the nature of the hypothetical "proximal" (mainly striated muscle originating) and "distal" (mainly smooth muscle originating) signals that govern the striated-for-smooth muscle replacement, we compared the esophagus of Myf5:MyoD null fetuses completely lacking striated muscle to the normal control using cDNA microarray analysis, followed by a comprehensive database search. Here we provide an insight into the nature of "proximal" and "distal" signals that govern the striated-for-smooth muscle replacement in the esophagus.

Original languageEnglish (US)
Pages (from-to)457-467
Number of pages11
JournalHistology and histopathology
Volume34
Issue number5
DOIs
StatePublished - May 1 2019
Externally publishedYes

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Striated Muscle
Esophagus
Smooth Muscle
Microarray Analysis
Pharynx
Oligonucleotide Array Sequence Analysis
Smooth Muscle Myocytes
Mouth
Stomach
Fetus
Parturition
Databases
Pregnancy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Striated-for-smooth muscle replacement in the developing mouse esophagus. / Baguma-Nibasheka, Mark; Fracassi, Anna; Costain, Willard J.; Moreno, Sandra; Kablar, Boris.

In: Histology and histopathology, Vol. 34, No. 5, 01.05.2019, p. 457-467.

Research output: Contribution to journalReview article

Baguma-Nibasheka, Mark ; Fracassi, Anna ; Costain, Willard J. ; Moreno, Sandra ; Kablar, Boris. / Striated-for-smooth muscle replacement in the developing mouse esophagus. In: Histology and histopathology. 2019 ; Vol. 34, No. 5. pp. 457-467.
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