Structural and Functional Alterations in the Zona Fasciculata of the Rat Adrenal Cortex in Obstructive Jaundice

Patrick Roughneen, K. M. Tallon, Diane Haley Russell, B. J. Rowlands

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This study investigated the effect of experimentally-induced cholestasis in the rat on the structure and function of the zona fasciculata, the glucocorticoid secretory region of the adrenal cortex. Wistar-Furth rats (200-250g) were assigned to three groups: bile duct ligated (BDL), Sham operated (Sham) and unmodified normal control (NC). On day 14, serum bilirubin and liver histology were performed to confirm cholestasis in BDL animals together with basal 24 hour 17-hydroxycorti-costeroid excretion, adrenal histology and zona fasciculata ultrastructure in all experimental groups. Following this laparotomy, structural and functional studies were repeated on day 15 to evaluate the response of the gland to surgically induced stress. Basal 24 hr. 17-hydroxycorticoid steroid excretion was elevated in BDL animals (26.9 ± 3.2 μ g/24 hr) with respect to Sham (10.4 ± 2.3) and NC groups (13.5 ± 3.2) (p

Original languageEnglish (US)
Pages (from-to)271-281
Number of pages11
JournalHPB Surgery
Volume1
Issue number4
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Zona Fasciculata
Obstructive Jaundice
Adrenal Cortex
Bile Ducts
Cholestasis
Histology
Inbred WF Rats
Bilirubin
Laparotomy
Glucocorticoids
Steroids
Control Groups
Liver
Serum

Keywords

  • adrenal cortex
  • cholestasis
  • obstructive jaundice
  • Zona fasciculata

ASJC Scopus subject areas

  • Hepatology
  • Surgery

Cite this

Structural and Functional Alterations in the Zona Fasciculata of the Rat Adrenal Cortex in Obstructive Jaundice. / Roughneen, Patrick; Tallon, K. M.; Haley Russell, Diane; Rowlands, B. J.

In: HPB Surgery, Vol. 1, No. 4, 1989, p. 271-281.

Research output: Contribution to journalArticle

Roughneen, Patrick ; Tallon, K. M. ; Haley Russell, Diane ; Rowlands, B. J. / Structural and Functional Alterations in the Zona Fasciculata of the Rat Adrenal Cortex in Obstructive Jaundice. In: HPB Surgery. 1989 ; Vol. 1, No. 4. pp. 271-281.
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