Structural Basis and Selectivity of Tankyrase Inhibition by a Wnt Signaling Inhibitor WIKI4

Keyphrases

• Wnt Inhibitors 100%
• Tankyrase Inhibitor 100%
• Binding Mode 50%
• Tankyrase 50%
• High Potency 25%
• Further Development 25%
• Cancer Cell Lines 25%
• Adenosine 25%
• Catenin 25%
• Wnt Signaling 25%
• Catalytic Domain 25%
• Novel Inhibitors 25%
• Human Embryonic Stem Cells (hESCs) 25%
• NAD+ Binding 25%
• Protein X-ray Crystallography 25%

Biochemistry, Genetics and Molecular Biology

• Wnt Signaling Pathway 100%
• Cancer Cell 50%
• Enzyme 50%
• Catenin 50%
• Enzyme Active Site 50%
• Embryonic Stem Cell 50%
• X-Ray Crystallography 50%
• Adenosine 50%