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Structural basis for differential binding of the interleukin-8 monomer and dimer to the CXCR1 N-domain: Role of coupled interactions and dynamics
Aishwarya Ravindran
, Prem Raj B. Joseph
,
Krishna Rajarathnam
Biochemistry & Molecular Biology
Research output
:
Contribution to journal
›
Article
›
peer-review
50
Scopus citations
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Dive into the research topics of 'Structural basis for differential binding of the interleukin-8 monomer and dimer to the CXCR1 N-domain: Role of coupled interactions and dynamics'. Together they form a unique fingerprint.
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Keyphrases
CXCR1
100%
Interleukin-8
100%
N-domain
100%
Differential Binding
100%
Coupled Dynamics
100%
Coupled Interaction
100%
Receptor Complex
40%
Dissociation
40%
Binding Mechanism
40%
Binding Affinity
40%
Dimer Interface
40%
Immune Response
20%
Conformational Change
20%
Interaction Games
20%
Disulfide
20%
CXCL8
20%
NMR Data
20%
Conformational Flexibility
20%
Unfavorable Interaction
20%
High-affinity Ligands
20%
NMR Chemical Shifts
20%
Interface Interaction
20%
Localized Events
20%
Intensity Change
20%
Non-sequential
20%
Biochemistry, Genetics and Molecular Biology
Dynamics
100%
Interleukin 8
100%
Binding Affinity
33%
G Protein Coupled Receptor
16%
Conformational Change
16%
Immune Response
16%
Disulfide
16%
Interleukin 8 Receptor, Alpha
16%