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Structural basis of selective inhibition of human tankyrases
Mohit Narwal
, Harikanth Venkannagari
, Lari Lehtiö
Research output
:
Contribution to journal
›
Article
›
peer-review
129
Scopus citations
Overview
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Dive into the research topics of 'Structural basis of selective inhibition of human tankyrases'. Together they form a unique fingerprint.
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Keyphrases
Selective Inhibition
100%
Tankyrase
100%
PARP Inhibitor (PARPi)
33%
Nicotinamide
33%
IWR-1
33%
Cancer Treatment
16%
Selective Inhibitor
16%
Binding Site
16%
Conformational Change
16%
Cell Behavior
16%
Poly(ADP-ribose) Polymerase
16%
Wnt Signaling
16%
Structure-activity Relationship
16%
Potent Inhibitor
16%
PARP Enzymes
16%
Olaparib
16%
PARP2
16%
Existing Structures
16%
Substrate Binding Loop
16%
Telomere Homeostasis
16%
Biochemistry, Genetics and Molecular Biology
Poly ADP Ribose Polymerase
100%
Crystal Structure
75%
Nicotinamide
50%
Enzyme
25%
Conformational Change
25%
Binding Site
25%
Cell Function
25%
Wnt Signaling Pathway
25%
Adenosine Diphosphate
25%
Structure Activity Relation
25%
Telomere Homeostasis
25%