TY - JOUR
T1 - Structural insight on processivity, human disease and antiviral drug toxicity
AU - Yin, Y. Whitney
PY - 2011/2
Y1 - 2011/2
N2 - DNA polymerase gamma (Pol γ) is a nuclear encoded, mitochondrially located replicase that conducts all DNA synthesis in the organelle. Structurally, human Pol γ closely resembles bacteriophage T7 DNA polymerase. Perhaps due to this prokaryotic-like feature, Pol γ is highly susceptible to inhibition by drugs designed against HIV reverse transcriptase and HCV RNA polymerase. In this review, I summarize recent structural and biochemical studies towards understanding Pol γ-mediated antiviral drug toxicity.
AB - DNA polymerase gamma (Pol γ) is a nuclear encoded, mitochondrially located replicase that conducts all DNA synthesis in the organelle. Structurally, human Pol γ closely resembles bacteriophage T7 DNA polymerase. Perhaps due to this prokaryotic-like feature, Pol γ is highly susceptible to inhibition by drugs designed against HIV reverse transcriptase and HCV RNA polymerase. In this review, I summarize recent structural and biochemical studies towards understanding Pol γ-mediated antiviral drug toxicity.
UR - http://www.scopus.com/inward/record.url?scp=79551684875&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79551684875&partnerID=8YFLogxK
U2 - 10.1016/j.sbi.2010.12.001
DO - 10.1016/j.sbi.2010.12.001
M3 - Review article
C2 - 21185718
AN - SCOPUS:79551684875
SN - 0959-440X
VL - 21
SP - 83
EP - 91
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 1
ER -