Structural insight on processivity, human disease and antiviral drug toxicity

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Abstract

DNA polymerase gamma (Pol γ) is a nuclear encoded, mitochondrially located replicase that conducts all DNA synthesis in the organelle. Structurally, human Pol γ closely resembles bacteriophage T7 DNA polymerase. Perhaps due to this prokaryotic-like feature, Pol γ is highly susceptible to inhibition by drugs designed against HIV reverse transcriptase and HCV RNA polymerase. In this review, I summarize recent structural and biochemical studies towards understanding Pol γ-mediated antiviral drug toxicity.

Original languageEnglish (US)
Pages (from-to)83-91
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume21
Issue number1
DOIs
StatePublished - Feb 2011
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

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