Structural insight on processivity, human disease and antiviral drug toxicity

Y. Whitney Yin

doi:10.1016/j.sbi.2010.12.001

Structural insight on processivity, human disease and antiviral drug toxicity

Y. Whitney Yin

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

DNA polymerase gamma (Pol γ) is a nuclear encoded, mitochondrially located replicase that conducts all DNA synthesis in the organelle. Structurally, human Pol γ closely resembles bacteriophage T7 DNA polymerase. Perhaps due to this prokaryotic-like feature, Pol γ is highly susceptible to inhibition by drugs designed against HIV reverse transcriptase and HCV RNA polymerase. In this review, I summarize recent structural and biochemical studies towards understanding Pol γ-mediated antiviral drug toxicity.

Original language	English (US)
Pages (from-to)	83-91
Number of pages	9
Journal	Current Opinion in Structural Biology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.sbi.2010.12.001
State	Published - Feb 2011
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/j.sbi.2010.12.001

Cite this

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abstract = "DNA polymerase gamma (Pol γ) is a nuclear encoded, mitochondrially located replicase that conducts all DNA synthesis in the organelle. Structurally, human Pol γ closely resembles bacteriophage T7 DNA polymerase. Perhaps due to this prokaryotic-like feature, Pol γ is highly susceptible to inhibition by drugs designed against HIV reverse transcriptase and HCV RNA polymerase. In this review, I summarize recent structural and biochemical studies towards understanding Pol γ-mediated antiviral drug toxicity.",

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AB - DNA polymerase gamma (Pol γ) is a nuclear encoded, mitochondrially located replicase that conducts all DNA synthesis in the organelle. Structurally, human Pol γ closely resembles bacteriophage T7 DNA polymerase. Perhaps due to this prokaryotic-like feature, Pol γ is highly susceptible to inhibition by drugs designed against HIV reverse transcriptase and HCV RNA polymerase. In this review, I summarize recent structural and biochemical studies towards understanding Pol γ-mediated antiviral drug toxicity.

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UR - https://www.scopus.com/pages/publications/79551684875#tab=citedBy

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DO - 10.1016/j.sbi.2010.12.001

M3 - Review article

C2 - 21185718

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JF - Current Opinion in Structural Biology

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Structural insight on processivity, human disease and antiviral drug toxicity

Abstract

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