Structural insights into the architecture of the hyperthermophilic fusellovirus SSV1

Kenneth M. Stedman, Melissa DeYoung, Mitul Saha, Michael Sherman, Marc Morais

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The structure and assembly of many icosahedral and helical viruses are well-characterized. However, the molecular basis for the unique spindle-shaped morphology of many viruses that infect Archaea remains unknown. To understand the architecture and assembly of these viruses, the spindle-shaped virus SSV1 was examined using cryo-EM, providing the first 3D-structure of a spindle-shaped virus as well as insight into SSV1 biology, assembly and evolution. Furthermore, a geometric framework underlying the distinct spindle-shaped structure is proposed.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalVirology
Volume474
DOIs
StatePublished - Jan 1 2015

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Keywords

  • Archaeal virus
  • Extremophile
  • Fullerene cone
  • Fusellovirus
  • Hyperthermophilic virus
  • Spindle-shaped virus
  • SSV
  • SSV1
  • Virus assembly
  • Virus structure

ASJC Scopus subject areas

  • Virology
  • Medicine(all)

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