Structural remodeling of cocaine: Design and synthesis of trisubstituted cyclopropanes as selective serotonin reuptake inhibitors

Alan P. Kozikowski, Lianyun Zhao, Ao Zhang, Cheng Z. Wang, Judith Flippen-Anderson, Kenneth M. Johnson

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Blocking transporters: A series of novel cyclopropane analogues 1 structurally related to cocaine were synthesized by using a sulfonium ylide based cyclopropanation reaction of benzylidenemalonate. As selective serotonin reuptake inhibitors (SSRIs) have proven effective against depression and other neurological disorders, these easily synthesized ligands are of potential therapeutic interest.

Original languageEnglish (US)
Pages (from-to)58-65
Number of pages8
JournalChemMedChem
Volume1
Issue number1
DOIs
StatePublished - Jan 2006

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Keywords

  • Cocaine
  • Cyclopropane
  • Monoamine inhibitors
  • Neurochemistry
  • Neurotransmitters

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry
  • Molecular Medicine

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