Blocking transporters: A series of novel cyclopropane analogues 1 structurally related to cocaine were synthesized by using a sulfonium ylide based cyclopropanation reaction of benzylidenemalonate. As selective serotonin reuptake inhibitors (SSRIs) have proven effective against depression and other neurological disorders, these easily synthesized ligands are of potential therapeutic interest.
- Monoamine inhibitors
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Organic Chemistry
- Molecular Medicine