Structural snapshots from the oxidative half-reaction of a copper amine oxidase

Implications for O2 activation

Bryan J. Johnson, Erik T. Yukl, Valerie J. Klema, Judith P. Klinman, Carrie M. Wilmot

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Copper amine oxidases activate O2 either at the copper center or aminoquinol cofactor. Results: Catalytic intermediates from the oxidative half-reaction are structurally and spectroscopically characterized. Conclusion: The mechanism of O2 activation may depend on accessibility dictated by two conformers of the quinone cofactor. Significance: Structural changes that inform on catalytic mechanism have been revealed in the ubiquitous copper amine oxidases.

Original languageEnglish (US)
Pages (from-to)28409-28417
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number39
DOIs
StatePublished - Sep 27 2013
Externally publishedYes

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Amine Oxidase (Copper-Containing)
Chemical activation
Copper
benzoquinone

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Structural snapshots from the oxidative half-reaction of a copper amine oxidase : Implications for O2 activation. / Johnson, Bryan J.; Yukl, Erik T.; Klema, Valerie J.; Klinman, Judith P.; Wilmot, Carrie M.

In: Journal of Biological Chemistry, Vol. 288, No. 39, 27.09.2013, p. 28409-28417.

Research output: Contribution to journalArticle

Johnson, Bryan J. ; Yukl, Erik T. ; Klema, Valerie J. ; Klinman, Judith P. ; Wilmot, Carrie M. / Structural snapshots from the oxidative half-reaction of a copper amine oxidase : Implications for O2 activation. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 39. pp. 28409-28417.
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