Structural studies of virus-antibody complexes by electron cryomicroscopy and X-ray crystallography

Wah Chiu, Thomas Smith

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The combined use of electron cryomicroscopy and X-ray crystallography has recently provided unprecedented and unique structural information of virus-antibody complexes. Different kinds of viral proteins have been located and identified on the capsid surface, certain residues of the viral proteins involved in antibody interactions have been identified; the elbow angle of bound antibody has been measured; and the mechanism of antibody-mediated neutralization has been elucidated. Within the next few years, this combined methodology should help investigators resolve the structures of large macromolecular assemblies to even higher resolutions.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume4
Issue number2
DOIs
StatePublished - 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

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