Structure activity relation for some 1,4-benzodiazepinones

correlation between rate constants for reduction by sodium borohydride and antileptazol ED50

V-M Ramanujam, N. M. Trieff

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Significant correlation in 11 different, 1,4-benzodiazepinones has been established between log k2 (the second order rate constant for the reduction of the 'azepinones' by sodium borohydride) and their ED50 against leptazol-induced seizures in mice. The results suggest a possible involvement of the carbonyl group at the receptor site.

Original languageEnglish (US)
Pages (from-to)542-546
Number of pages5
JournalJournal of Pharmacy and Pharmacology
Volume30
Issue number9
StatePublished - 1978

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Benzodiazepinones
Seizures
sodium borohydride

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Structure activity relation for some 1,4-benzodiazepinones : correlation between rate constants for reduction by sodium borohydride and antileptazol ED50. / Ramanujam, V-M; Trieff, N. M.

In: Journal of Pharmacy and Pharmacology, Vol. 30, No. 9, 1978, p. 542-546.

Research output: Contribution to journal › Article

Ramanujam, V-M & Trieff, NM 1978, 'Structure activity relation for some 1,4-benzodiazepinones: correlation between rate constants for reduction by sodium borohydride and antileptazol ED50', Journal of Pharmacy and Pharmacology, vol. 30, no. 9, pp. 542-546.
Ramanujam V-M, Trieff NM. Structure activity relation for some 1,4-benzodiazepinones: correlation between rate constants for reduction by sodium borohydride and antileptazol ED50. Journal of Pharmacy and Pharmacology. 1978;30(9):542-546.
Ramanujam, V-M ; Trieff, N. M. / Structure activity relation for some 1,4-benzodiazepinones : correlation between rate constants for reduction by sodium borohydride and antileptazol ED50. In: Journal of Pharmacy and Pharmacology. 1978 ; Vol. 30, No. 9. pp. 542-546.
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