Abstract
Significant correlation in 11 different, 1,4-benzodiazepinones has been established between log k2 (the second order rate constant for the reduction of the 'azepinones' by sodium borohydride) and their ED50 against leptazol-induced seizures in mice. The results suggest a possible involvement of the carbonyl group at the receptor site.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 542-546 |
| Number of pages | 5 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 30 |
| Issue number | 9 |
| State | Published - 1978 |
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ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology
Cite this
Structure activity relation for some 1,4-benzodiazepinones : correlation between rate constants for reduction by sodium borohydride and antileptazol ED50. / Ramanujam, V-M; Trieff, N. M.
In: Journal of Pharmacy and Pharmacology, Vol. 30, No. 9, 1978, p. 542-546.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structure activity relation for some 1,4-benzodiazepinones
T2 - correlation between rate constants for reduction by sodium borohydride and antileptazol ED50
AU - Ramanujam, V-M
AU - Trieff, N. M.
PY - 1978
Y1 - 1978
N2 - Significant correlation in 11 different, 1,4-benzodiazepinones has been established between log k2 (the second order rate constant for the reduction of the 'azepinones' by sodium borohydride) and their ED50 against leptazol-induced seizures in mice. The results suggest a possible involvement of the carbonyl group at the receptor site.
AB - Significant correlation in 11 different, 1,4-benzodiazepinones has been established between log k2 (the second order rate constant for the reduction of the 'azepinones' by sodium borohydride) and their ED50 against leptazol-induced seizures in mice. The results suggest a possible involvement of the carbonyl group at the receptor site.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018077198&partnerID=8YFLogxK
M3 - Article
C2 - 29091
AN - SCOPUS:0018077198
VL - 30
SP - 542
EP - 546
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 9
ER -