Structure activity relation for some 1,4-benzodiazepinones

correlation between rate constants for reduction by sodium borohydride and antileptazol ED50

V-M Ramanujam, N. M. Trieff

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2 Citations (Scopus)

Abstract

Significant correlation in 11 different, 1,4-benzodiazepinones has been established between log k2 (the second order rate constant for the reduction of the 'azepinones' by sodium borohydride) and their ED50 against leptazol-induced seizures in mice. The results suggest a possible involvement of the carbonyl group at the receptor site.

Original languageEnglish (US)
Pages (from-to)542-546
Number of pages5
JournalJournal of Pharmacy and Pharmacology
Volume30
Issue number9
StatePublished - 1978

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Benzodiazepinones
Seizures
sodium borohydride

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

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title = "Structure activity relation for some 1,4-benzodiazepinones: correlation between rate constants for reduction by sodium borohydride and antileptazol ED50",
abstract = "Significant correlation in 11 different, 1,4-benzodiazepinones has been established between log k2 (the second order rate constant for the reduction of the 'azepinones' by sodium borohydride) and their ED50 against leptazol-induced seizures in mice. The results suggest a possible involvement of the carbonyl group at the receptor site.",
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