Structure activity relation for some 1,4‐benzodiazepinones: correlation between rate constants for reduction by sodium borohydride and antileptazol ED 50

V. M.SADAGOPA RAMANUJAM, NORMAN M. TRIEFF

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Significant correlation in 11 different 1,4‐benzodiazepinones has been established between log k2 (the second order rate constant for the reduction of the ‘azepinones’ by sodium borohydride) and their ED50 against leptazol‐induced seizures in mice. The results suggest a possible involvement of the carbonyl group at the receptor site. 1978 Royal Pharmaceutical Society of Great Britain

Original languageEnglish (US)
Pages (from-to)542-546
Number of pages5
JournalJournal of Pharmacy and Pharmacology
Volume30
Issue number1
DOIs
StatePublished - Sep 1978

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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