TY - JOUR
T1 - Structure activity relation for some 1,4‐benzodiazepinones
T2 - correlation between rate constants for reduction by sodium borohydride and antileptazol ED 50
AU - RAMANUJAM, V. M.SADAGOPA
AU - TRIEFF, NORMAN M.
PY - 1978/9
Y1 - 1978/9
N2 - Significant correlation in 11 different 1,4‐benzodiazepinones has been established between log k2 (the second order rate constant for the reduction of the ‘azepinones’ by sodium borohydride) and their ED50 against leptazol‐induced seizures in mice. The results suggest a possible involvement of the carbonyl group at the receptor site. 1978 Royal Pharmaceutical Society of Great Britain
AB - Significant correlation in 11 different 1,4‐benzodiazepinones has been established between log k2 (the second order rate constant for the reduction of the ‘azepinones’ by sodium borohydride) and their ED50 against leptazol‐induced seizures in mice. The results suggest a possible involvement of the carbonyl group at the receptor site. 1978 Royal Pharmaceutical Society of Great Britain
UR - http://www.scopus.com/inward/record.url?scp=0018077198&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018077198&partnerID=8YFLogxK
U2 - 10.1111/j.2042-7158.1978.tb13320.x
DO - 10.1111/j.2042-7158.1978.tb13320.x
M3 - Article
C2 - 29091
AN - SCOPUS:0018077198
SN - 0022-3573
VL - 30
SP - 542
EP - 546
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 1
ER -