Structure-activity relationship studies of cocaine: Replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue

Alan P. Kozikowski, Marinella Roberti, Li Xiang, John S. Bergmann, Patrick M. Callahan, Kathryn Cunningham, Kenneth M. Johnson

Research output: Contribution to journalArticle

71 Citations (Scopus)
Original languageEnglish
Pages (from-to)4764-4766
Number of pages3
JournalJournal of Medicinal Chemistry
Volume35
Issue number25
StatePublished - 1992

Fingerprint

Mazindol
Discrimination Learning
Competitive Binding
Esterases
Structure-Activity Relationship
Cocaine
Brain
calcium ascorbate

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Structure-activity relationship studies of cocaine : Replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue. / Kozikowski, Alan P.; Roberti, Marinella; Xiang, Li; Bergmann, John S.; Callahan, Patrick M.; Cunningham, Kathryn; Johnson, Kenneth M.

In: Journal of Medicinal Chemistry, Vol. 35, No. 25, 1992, p. 4764-4766.

Research output: Contribution to journalArticle

Kozikowski, Alan P. ; Roberti, Marinella ; Xiang, Li ; Bergmann, John S. ; Callahan, Patrick M. ; Cunningham, Kathryn ; Johnson, Kenneth M. / Structure-activity relationship studies of cocaine : Replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue. In: Journal of Medicinal Chemistry. 1992 ; Vol. 35, No. 25. pp. 4764-4766.
@article{615faccc346c460dbbc0e742694e2246,
title = "Structure-activity relationship studies of cocaine: Replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue",
author = "Kozikowski, {Alan P.} and Marinella Roberti and Li Xiang and Bergmann, {John S.} and Callahan, {Patrick M.} and Kathryn Cunningham and Johnson, {Kenneth M.}",
year = "1992",
language = "English",
volume = "35",
pages = "4764--4766",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "25",

}

TY - JOUR

T1 - Structure-activity relationship studies of cocaine

T2 - Replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue

AU - Kozikowski, Alan P.

AU - Roberti, Marinella

AU - Xiang, Li

AU - Bergmann, John S.

AU - Callahan, Patrick M.

AU - Cunningham, Kathryn

AU - Johnson, Kenneth M.

PY - 1992

Y1 - 1992

UR - http://www.scopus.com/inward/record.url?scp=0027064877&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027064877&partnerID=8YFLogxK

M3 - Article

C2 - 1469704

AN - SCOPUS:0027064877

VL - 35

SP - 4764

EP - 4766

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 25

ER -