Structure and morphogenesis of bacteriophage T4

Petr Leiman, S. Kanamaru, V. V. Mesyanzhinov, F. Arisaka, M. G. Rossmann

Research output: Contribution to journalReview article

166 Citations (Scopus)

Abstract

Bacteriophage T4 is one of the most complex viruses. More than 40 different proteins form the mature virion, which consists of a protein shell encapsidating a 172-kbp double-stranded genomic DNA, a 'tail,' and fibers, attached to the distal end of the tail. The fibers and the tail carry the host cell recognition sensors and are required for attachment of the phage to the cell surface. The tail also serves as a channel for delivery of the phage DNA from the head into the host cell cytoplasm. The tail is attached to the unique 'portal' vertex of the head through which the phage DNA is packaged during head assembly. Similar to other phages, and also herpes viruses, the unique vertex is occupied by a dodecameric portal protein, which is involved in DNA packaging.

Original languageEnglish (US)
Pages (from-to)2356-2370
Number of pages15
JournalCellular and Molecular Life Sciences
Volume60
Issue number11
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Bacteriophage T4
Bacteriophages
Morphogenesis
Head
DNA
Viruses
DNA Packaging
Proteins
Virion
Fibers
Cytoplasm
Packaging
Sensors

Keywords

  • Bacteriophage T4
  • Baseplate
  • Contractile tail
  • DNA packaging
  • Fibrous protein
  • Phage infection
  • Prolate head capsid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

Leiman, P., Kanamaru, S., Mesyanzhinov, V. V., Arisaka, F., & Rossmann, M. G. (2003). Structure and morphogenesis of bacteriophage T4. Cellular and Molecular Life Sciences, 60(11), 2356-2370. https://doi.org/10.1007/s00018-003-3072-1

Structure and morphogenesis of bacteriophage T4. / Leiman, Petr; Kanamaru, S.; Mesyanzhinov, V. V.; Arisaka, F.; Rossmann, M. G.

In: Cellular and Molecular Life Sciences, Vol. 60, No. 11, 11.2003, p. 2356-2370.

Research output: Contribution to journalReview article

Leiman, P, Kanamaru, S, Mesyanzhinov, VV, Arisaka, F & Rossmann, MG 2003, 'Structure and morphogenesis of bacteriophage T4', Cellular and Molecular Life Sciences, vol. 60, no. 11, pp. 2356-2370. https://doi.org/10.1007/s00018-003-3072-1
Leiman, Petr ; Kanamaru, S. ; Mesyanzhinov, V. V. ; Arisaka, F. ; Rossmann, M. G. / Structure and morphogenesis of bacteriophage T4. In: Cellular and Molecular Life Sciences. 2003 ; Vol. 60, No. 11. pp. 2356-2370.
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