Structure elucidation and complete NMR spectral assignments of three new lanostanoid triterpenes with unprecedented Δ16,17 double bond from Ganoderma lucidum

Shu Hong Guan; Min Yang; Xiao Ming Wang; Jia Meng Xia; Zhi Ming Zhang; Xuan Liu; De An Guo

doi:10.1002/mrc.2046

Structure elucidation and complete NMR spectral assignments of three new lanostanoid triterpenes with unprecedented Δ^16,17 double bond from Ganoderma lucidum

Shu Hong Guan
, Min Yang
, Xiao Ming Wang
, Jia Meng Xia
, Zhi Ming Zhang
, Xuan Liu
, De An Guo

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Three new lanostanoid triterpenes named 3β,7β-dihydroxy-11,15,23- trioxo-lanost-8,16-dien-26-oic acid (1), 3β,7β-dlhydroxy-11,15,23- trioxo-lanost-8,16-dien-26-oic acid methyl ester (2), and 12β-acetoxy- 3β7β-dihydroxy11,15,23-trioxo-lanost-8,16-dien-26-oic acid (3) were isolated from the fruit bodies of Ganoderma lucidum. They all show a Δ^16,17 double bond unprecedented in such types of lanostanoid triterpenes possessing the side chain at C-17. The complete NMR assignments for these compounds were carried out using ¹H, ¹³C, DEPT, COSY, HSQC, HMBC, and ROESY NMR experiments.

Original language	English (US)
Pages (from-to)	789-791
Number of pages	3
Journal	Magnetic Resonance in Chemistry
Volume	45
Issue number	9
DOIs	https://doi.org/10.1002/mrc.2046
State	Published - Sep 2007
Externally published	Yes

Keywords

C
Ganoderma lucidum
H
Lanostanoid triterpenes
NMR

ASJC Scopus subject areas

General Chemistry
General Materials Science

Access to Document

10.1002/mrc.2046

Cite this

@article{23d4f244ece0476898351357727ee9c6,

title = "Structure elucidation and complete NMR spectral assignments of three new lanostanoid triterpenes with unprecedented Δ16,17 double bond from Ganoderma lucidum",

abstract = "Three new lanostanoid triterpenes named 3β,7β-dihydroxy-11,15,23- trioxo-lanost-8,16-dien-26-oic acid (1), 3β,7β-dlhydroxy-11,15,23- trioxo-lanost-8,16-dien-26-oic acid methyl ester (2), and 12β-acetoxy- 3β7β-dihydroxy11,15,23-trioxo-lanost-8,16-dien-26-oic acid (3) were isolated from the fruit bodies of Ganoderma lucidum. They all show a Δ16,17 double bond unprecedented in such types of lanostanoid triterpenes possessing the side chain at C-17. The complete NMR assignments for these compounds were carried out using 1H, 13C, DEPT, COSY, HSQC, HMBC, and ROESY NMR experiments.",

keywords = "C, Ganoderma lucidum, H, Lanostanoid triterpenes, NMR",

author = "Guan, \{Shu Hong\} and Min Yang and Wang, \{Xiao Ming\} and Xia, \{Jia Meng\} and Zhang, \{Zhi Ming\} and Xuan Liu and Guo, \{De An\}",

year = "2007",

month = sep,

doi = "10.1002/mrc.2046",

language = "English (US)",

volume = "45",

pages = "789--791",

journal = "Magnetic Resonance in Chemistry",

issn = "0749-1581",

publisher = "John Wiley and Sons Ltd",

number = "9",

}

TY - JOUR

T1 - Structure elucidation and complete NMR spectral assignments of three new lanostanoid triterpenes with unprecedented Δ16,17 double bond from Ganoderma lucidum

AU - Guan, Shu Hong

AU - Yang, Min

AU - Wang, Xiao Ming

AU - Xia, Jia Meng

AU - Zhang, Zhi Ming

AU - Liu, Xuan

AU - Guo, De An

PY - 2007/9

Y1 - 2007/9

N2 - Three new lanostanoid triterpenes named 3β,7β-dihydroxy-11,15,23- trioxo-lanost-8,16-dien-26-oic acid (1), 3β,7β-dlhydroxy-11,15,23- trioxo-lanost-8,16-dien-26-oic acid methyl ester (2), and 12β-acetoxy- 3β7β-dihydroxy11,15,23-trioxo-lanost-8,16-dien-26-oic acid (3) were isolated from the fruit bodies of Ganoderma lucidum. They all show a Δ16,17 double bond unprecedented in such types of lanostanoid triterpenes possessing the side chain at C-17. The complete NMR assignments for these compounds were carried out using 1H, 13C, DEPT, COSY, HSQC, HMBC, and ROESY NMR experiments.

AB - Three new lanostanoid triterpenes named 3β,7β-dihydroxy-11,15,23- trioxo-lanost-8,16-dien-26-oic acid (1), 3β,7β-dlhydroxy-11,15,23- trioxo-lanost-8,16-dien-26-oic acid methyl ester (2), and 12β-acetoxy- 3β7β-dihydroxy11,15,23-trioxo-lanost-8,16-dien-26-oic acid (3) were isolated from the fruit bodies of Ganoderma lucidum. They all show a Δ16,17 double bond unprecedented in such types of lanostanoid triterpenes possessing the side chain at C-17. The complete NMR assignments for these compounds were carried out using 1H, 13C, DEPT, COSY, HSQC, HMBC, and ROESY NMR experiments.

KW - C

KW - Ganoderma lucidum

KW - H

KW - Lanostanoid triterpenes

KW - NMR

UR - https://www.scopus.com/pages/publications/34548090013

UR - https://www.scopus.com/pages/publications/34548090013#tab=citedBy

U2 - 10.1002/mrc.2046

DO - 10.1002/mrc.2046

M3 - Article

C2 - 17640004

AN - SCOPUS:34548090013

SN - 0749-1581

VL - 45

SP - 789

EP - 791

JO - Magnetic Resonance in Chemistry

JF - Magnetic Resonance in Chemistry

IS - 9

ER -