Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity

Keyphrases

• Binding Energy 50%
• Binding Mode 50%
• Binding Module 50%
• Dimeric Compound 50%
• Hairpin 50%
• Hydrogen Bonds (H-bonds) 100%
• Internal Loop 100%
• Major Groove 50%
• Molecular Dynamics Simulation 100%
• Multivalent 50%
• Myotonic Dystrophy Type 2 100%
• Na + 50%
• Neuromuscular Disease 50%
• Optimal Distance 50%
• Reduced Toxicity 100%
• RNA Binding 50%
• RNA-small Molecule Interactions 50%
• Small Molecules 100%
• Water Molecule 50%
• Water-mediated Hydrogen Bonds 50%

Biochemistry, Genetics and Molecular Biology

• Binding Energy 33%
• Crystal Structure 33%
• Hydrogen Bond 100%
• RNA 100%
• RNA Binding 33%
• Small Molecule 100%