Structure of yellow fever virus envelope protein domain III

David E. Volk, Fiona J. May, Sai H.A. Gandham, Anjenique Anderson, Jana J. Von Lindern, David W.C. Beasley, Alan D.T. Barrett, David G. Gorenstein

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The structure of recombinant domain III of the envelope protein (rED3) of yellow fever virus (YFV), containing the major neutralization site, was determined using NMR spectroscopy. The amino acid sequence and structure of the YFV-rED3 shows differences from ED3s of other mosquito-borne flaviviruses; in particular, the partially surface-exposed BC loop where methionine-304 and valine-324 were identified as being critical for the structure of the loop. Variations in the structure and surface chemistry of ED3 between flaviviruses affect neutralization sites and may affect host cell receptor interactions and play a role in the observed variations in viral pathogenesis and tissue tropism.

Original languageEnglish (US)
Pages (from-to)12-18
Number of pages7
JournalVirology
Volume394
Issue number1
DOIs
StatePublished - Nov 10 2009

Keywords

  • Envelope protein domain III
  • Flavivirus
  • Neutralization site
  • Yellow fever virus

ASJC Scopus subject areas

  • Virology

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