Structure/function relationships in OmpR and other winged-helix transcription factors

Linda J. Kenney

doi:10.1016/S1369-5274(02)00310-7

Structure/function relationships in OmpR and other winged-helix transcription factors

Linda J. Kenney

Research output: Contribution to journal › Review article › peer-review

138 Scopus citations

Abstract

Response regulators are the output component of two-component regulatory systems, the predominant form of signal transduction systems utilized by prokaryotes. The majority of response regulators function as transcription factors, yet detailed descriptions of their mechanisms of DNA binding and its consequences are lacking. Versatility in the modes of DNA binding is evident with winged helix-turn-helix proteins, raising doubts that mechanisms of DNA binding will be generalizable among members of the family. The current focus of some of the research efforts aimed at understanding activation and DNA binding by response regulators is highlighted in this review.

Original language	English (US)
Pages (from-to)	135-141
Number of pages	7
Journal	Current Opinion in Microbiology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/S1369-5274(02)00310-7
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases

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10.1016/S1369-5274(02)00310-7

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title = "Structure/function relationships in OmpR and other winged-helix transcription factors",

abstract = "Response regulators are the output component of two-component regulatory systems, the predominant form of signal transduction systems utilized by prokaryotes. The majority of response regulators function as transcription factors, yet detailed descriptions of their mechanisms of DNA binding and its consequences are lacking. Versatility in the modes of DNA binding is evident with winged helix-turn-helix proteins, raising doubts that mechanisms of DNA binding will be generalizable among members of the family. The current focus of some of the research efforts aimed at understanding activation and DNA binding by response regulators is highlighted in this review.",

author = "Kenney, {Linda J.}",

note = "Funding Information: LJK is grateful to the following for helpful discussions: Ann Maris (UCLA), Vic DiRita (University of Michigan) and KI Varughese (Scripps Research Institute). LJK thanks Jack H Kaplan for providing a high hurdle while striving for clarity, and Barry Wanner (Purdue University) and laboratory members X Feng, K Mattison, R Oropeza and DM Walthers for their comments on the manuscript. Ted Michelini (OHSU) created Fig. 3 . Supported by National Institutes of Health GM58746 and National Science Foundation MCB9904658 to LJK. ",

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N2 - Response regulators are the output component of two-component regulatory systems, the predominant form of signal transduction systems utilized by prokaryotes. The majority of response regulators function as transcription factors, yet detailed descriptions of their mechanisms of DNA binding and its consequences are lacking. Versatility in the modes of DNA binding is evident with winged helix-turn-helix proteins, raising doubts that mechanisms of DNA binding will be generalizable among members of the family. The current focus of some of the research efforts aimed at understanding activation and DNA binding by response regulators is highlighted in this review.

AB - Response regulators are the output component of two-component regulatory systems, the predominant form of signal transduction systems utilized by prokaryotes. The majority of response regulators function as transcription factors, yet detailed descriptions of their mechanisms of DNA binding and its consequences are lacking. Versatility in the modes of DNA binding is evident with winged helix-turn-helix proteins, raising doubts that mechanisms of DNA binding will be generalizable among members of the family. The current focus of some of the research efforts aimed at understanding activation and DNA binding by response regulators is highlighted in this review.

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Structure/function relationships in OmpR and other winged-helix transcription factors

Abstract

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