Studies of androgen production and binding in 13 male pseudohermaphrodites and 13 males with micropenis

James A. Amrhein, Walter J. Meyer, Robert K. Danish, Claude J. Migeon

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10 Scopus citations

Abstract

We studied androgen production by morphologic and biochemical criteria plus androgen binding by skin fibroblasts in 13 male pseudohermaphrodites and 13 males with micropenis, none of whom had evidence of androgen insensitivity. Seventeen of the 26 patients had evidence of deficient androgen production, suggesting this as the cause of their incomplete virilization in utero. Fibroblasts from all 26 patients demonstrated normal androgen binding and affinity of the steroid for the receptor. Although these results exclude a deficiency of androgen binding in these individuals, other end organ defects are possible. Guidelines for diagnosis and management of such patients are presented.

Original languageEnglish (US)
Pages (from-to)732-738
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume45
Issue number4
DOIs
StatePublished - Oct 1977

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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