Studies of single molecules in their natural form

Moshe Lindner, Guy Nir, Heidelinde R.C. Dietrich, Ian T. Young, Elad Tauber, I. Bronshtein, Liat Altman, Yuval Garini

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Single molecule studies make possible the characterization of molecular processes and the identification of biophysical sub-populations that are not accessible through ensemble studies. We describe tethered particle motion, a method that allows one to study single molecules in their natural form without having to apply any external forces. The method combines darkfield microscopy with a metal nanobead. It permits the study of the biophysical properties of the tethered particles, as well as protein-DNA interactions. The method is not suitable for in vivo studies, and we therefore describe two other methods that are appropriate for live-cell imaging.

Original languageEnglish (US)
Pages (from-to)283-291
Number of pages9
JournalIsrael Journal of Chemistry
Issue number3-4
StatePublished - Apr 2009
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry


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